Therapeutic Approaches
What are 5 imaging methods for HD?
MRI, fMRI, DTI, MRS, PET
Are FNPs pluripotent or multipotent?
multipotent
HD is characterized by the loss of what in which brain region?
MSNs in striatum
What over-the-counter medication could possibly reduce the risk of development of Alzheimer's and Parkinson's?
Ibuprofen
What three approaches are the most promising?
Antisense Oligonucleotides (ASOs), RNA interference (RNAi), & Zinc Fingerprinting
What 3 issues do primary fetal cells present?
Scarce, difficult to standardize, cannot be stored long-term
What motor movements are affected by HD? What are the symptoms/names for these?
What is the main cause of death in HD patients?
Unknown
or
Possibly cancer
What are two mice models for Huntington's Disease?
Conditional knockout model and Nucleotide based gene silencing
hFNP grafts lack organization in what zones?
P-zones and non-P zones
What is the CAP equation?
AGE × (CAG – L)
What peripheral metabolic pathway is affected in Huntington's disease?
Tryptophan Metabolism
What is a potential risk for using gene silencing as a therapeutic approach? (more than one correct answer)
Lowering the WT HTT gene
Toxicity or neuroinflammation from synthetic oligonucleotides
Immunogenicity when using AAV-delivered compounds
What is the peak period of MSN neurogenesis in humans?
8-10 weeks gestation
What cures Huntingtons disease?
Trick Question! There's still no cure, but we're getting close!
Sleep phenotypes associated with mHTT are not socially mediated between cohabiting mutation carriers
true or false
false
Biomarkers related to what are likely to be important in the future?
Neuronal cell death and neuronal cell dysfunction
Name the 3 main pluripotency markers?
alkaline phosphatase (AP), Oct-4, SSEA-1
What disorder is caused by a mutation in chromosome 4?
Huntington's Disease!
What experimental immune modulator drug is currently under investigation in multiple sclerosis trials?
Laquinimod