Introduction
"Breathing 100% oxygen under increased atmospheric pressure to treat high-mountain sickness" describes:
Hyperbaric Oxygen Therapy
120 of these rats were used in the study
Adult male Wistar
HSP-70 antibody had what effect on the Hyperbaric Oxygen Therapy outcomes?
Reduced or attenuated
Hyperbaric Oxygen Therapy was shown to have which effects?:
a) increased inflammation
b) decreased apoptotic cell death
c) increased cerebral edema
d) decreased neural regeneration
b)
What is characterized by cerebral and pulmonary edema and cognitive dysfunction after high altitude exposure (HAE)?
High-mountain sickness
What were the two cognitive functions the rats were tested in?
Passive Avoidance Learning and Spatial Memory Function
Hyperbaric Oxygen Therapy had which of the following effects on HAE Rats:
a) Increased oxidative stress markers
b) Attenuated cognitive deficits
c) Decreased antioxidant enzymes in the brain
d) All of the above
b)
For what other scenario involving changes in atmospheric pressure might Hyperbaric Oxygen Therapy be an effective treatment?
Diving (Decompression Sickness)
This protein is induced by several physiological or pathological stressors to protect against subsequent damage by increasing the tolerance of affected cells
Heat-Shock Protein - 70
What statistical analysis was performed on the data? (NOT post-hoc)
Repeated measures ANOVA
What were the three proinflammatory cytokine markers of lung inflammation in the bronchoalveolar fluid (BAL)?:
IL-6, IL-1Beta, TNF-alpha
What other illness might hyperbaric oxygen therapy be effective in treating (Hint: Competition for haemoglobin)?
Carbon Monoxide Poisoning