Disease Processes & Perfusion
This disease process involves plaque buildup in arterial walls, reducing blood flow.
What is atherosclerosis?
This lipid is often labeled “bad cholesterol.”
What is LDL?
This first-line drug class inhibits HMG-CoA reductase.
What are statins?
This serious statin adverse effect involves muscle breakdown.
What is rhabdomyolysis?
A patient with high LDL is most likely to be started on this drug class first.
What are statins?
This condition is characterized by elevated LDL and/or triglycerides contributing to impaired perfusion.
What is hyperlipidemia?
This lipid helps remove cholesterol from arteries.
What is HDL?
This class works by binding bile acids in the intestine.
What are bile acid sequestrants?
Statins commonly require monitoring of this organ due to potential toxicity.
What is the liver?
A patient with very high triglycerides (>500) may receive this drug class.
What are fibrates?
This mechanism explains how plaques reduce perfusion by narrowing vessels and limiting oxygen delivery.
What is decreased lumen diameter leading to ischemia?
This lab value is the primary target of most antilipidemic therapies.
What is LDL cholesterol?
This class primarily lowers triglycerides and can raise HDL.
What are fibrates?
Fibrates increase risk of this when combined with statins.
What is myopathy?
This drug would be added if statins alone do not achieve LDL goals.
What is ezetimibe?
This acute event occurs when a plaque ruptures, leading to clot formation and blocked perfusion.
What is thrombosis (or acute coronary syndrome)?
Triglyceride levels above this approximate value increase risk for pancreatitis.
What is >500 mg/dL?
This medication reduces cholesterol absorption in the small intestine.
What is ezetimibe?
This side effect of bile acid sequestrants affects the GI system.
What is constipation (or bloating)?
This class is often reserved for patients with familial hypercholesterolemia.
What are PCSK9 inhibitors?
Chronic reduced perfusion to extremities due to arterial narrowing is known as this condition.
What is peripheral artery disease (PAD)?
This calculation includes LDL, HDL, and triglycerides to assess cardiovascular risk.
What is total cholesterol (or lipid panel)?
This newer class increases LDL receptor recycling using monoclonal antibodies.
What are PCSK9 inhibitors?
PCSK9 inhibitors are commonly associated with this route-related reaction.
What is injection site reaction?
A patient intolerant to statins may benefit from this alternative class.
What are bile acid sequestrants (or ezetimibe)?