Bacteria
Sensitivity to this agent differentiates S. pneumonia vs. S. Mutans.
What is optochin?
This receptor can be found on the surface of macrophages and recognizes LPS.
What is TLR4?
This signaling confers commitment to the T-cell lineage.
What is Notch and IL-7 Signaling?
The presence of these two globulins signal that B cell development is complete in the bone marrow.
What is IgM and IgD?
This disease results from a lack of CD4+ T cells.
This Neisseria virulence factor confers resistance to phagocytosis.
What is the polysaccharide capsule?
Adhesion molecule pair that allows for tight binding in the process of extravasation.
What is ICAM and LFA?
The protein that allows thymocytes to see tissue-specific proteins during in the medulla (not oblongata)
What is AIRE (autoimmune regulator)?
The amount of chances you get to successfully rearrange the V(D)J heavy and light chains respectively.
What is 2 and 4 chances?
The enzyme that causes Chronic granulomatous disease when absent.
What is NADPH oxidase?
Aerobic gram-positive spore former that produces toxins that cause lethal necrosis and edema. Can be acquired through cutaneous, inhalation, gastrointestinal, or intravenous means.
Bacillus anthracis
anthrax toxins - Letha factor, and edema factor
These acute phase proteins acts as opsonins and complement activators.
What is c-reactive protein and mannose-binding lectin?
The success of this process leads to the generation of a double positive cell expressing CD4 and CD8.
What is successful beta-chain rearrangement and pre-TCR formation?
What is a pro-B-cell?
Disease resulting from failed VDJ recombination leading to recurrent viral, bacterial, and fungal infections.
What is severe combined immunodeficiency disorder (SCID)?
This gram-positive anaerobe secretes alpha and enterotoxin that cause hemolysis and food poisoning respectively.
What is Clostridium perfringens?
You wont find me in healthy tissue but I tend to die and leave behind pus in infected tissue.
What is a neutrophil?
Selection meditated by self-antigen/MHC complexes is carried out by these cells.
During the small pre-B cell stage this light chain is rearranged first.
What is the kappa light chain?
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by a defect in this protein.
What is AIRE (autoimmune regulator)
The combination therapy used to treat M. Tuberculosis infection.
BONUS: What are the mechanism of action?
Rifampin, Isoniazid, Pyrizinamide, Ethambutol (RIPE)
RIF - inhibits DNA-dependent RNA pol
INH - inhibits mycolic acid synthesis
PZA - inhibits translation (RpsA specifically)
EMB -inhibits arabinogalactan synthesis (prevent antibiotic resistance)
The classical C3 convertase.
What is C4bC2a?
The processes that assure the recognition of self-MHC and non self-reactive T cells respectively.
(must pair answers correctly)
What is positive and negative selection?
Positive selection for B cells.
What is Baff-dependent entrance into the follicle of the spleen.
A defect in this protein leads to X-linked agammaglobulinemia (loss of B cells).
What is Btk or Bruton's tyrosine kinase?