Knowledge
What is the chemical formula of Ibuprofen?
C13H1802
Name the two most popular ways to make ibuprofen.
Boot’s synthesis and the Green synthesis.
Name one catalyst that is used in the Green synthesis process.
HF (Hydrogen Fluoride)
or
Raney Nickel
or
Palladium
How can you make Advil work faster?
Increase the concentration of ibuprofen by taking 2 pills.
Name 2 Brands of ibuproben
Advil and Motrin
How many steps are involved in Boot's synthesis process?
6
Which catalyst is used in Boot's process?
(Hint- not a "true" catalyst)
AlCl3 (Aluminum Trichloride)
Which method can be used to determine the mass of ibuprofen in Advil?
Monoprotic titrations
What are 2 chemical properties of Ibuprofen?
Melting point- 74-77°C
Molecular Weight- 206.28082 g/mol
Formal Charge- 0
Isotope Atom Count- 0
Topological Polar Surface Area- 37.3 A²
Physical Description- Solid
Colour- Colourless, white crystalline stable solid
Odor- Characteristic odor
Solubility-Very soluble in alcohol, Slightly soluble in water
Water solubility- 21 mg/L (at 25°C)
Stability- Stable
pKa- 4.91
How many steps are involved in Green synthesis process?
3
Catalysts work by lowering the *BLANK* of a chemical reaction.
Activation Energy
Which class of enzymes is inhibited by ibuprofen?
cyclooxygenases (COX) enzymes
Name 2 non steroidal anti-inflammatory drugs (NSAID).
Any 2 of the following:
Ibuprofen
Acetaminophen
Aspirin
In which process is the following reaction carried out?
CaF2 + H2SO4 → 2 HF + CaSO4
Green Synthesis
Why is Aluminum trichloride not a true catalyst?
It cannot be recovered at the end of the chemical reaction.
Name 3 benefits of using the Green synthesis process instead of the Boot's process.
- Waste prevention
-Safe chemicals design
-Energy efficiency
-Inherently safe chemistry
-Less time consuming
-Design for degradation