ACTIMMUNE (ri)
How is Actimmune administered? ROA
SUBCUTANEOUSLY (SQ)
Through which route is Nulojix administered?
Intravenously
The minimum age required to use hympavzi
12 years old
What is the route of administration that is used for Xenopozyme therapy
What is intravenous infusion
What is Actimmune used to treat?
Used to reduce the frequency and severity of chronic granulomatous disease and for delaying time for disease progression in severe, malignant osteopetrosis
Nulojix is indicated for prophylaxis of organ rejections in adults receiving this transplant.
Kidney
If on maintenance dosing and more than ___ days have passed since last infusion, a loading dose is required before resuming maintenance dosing
A. 1 day
B. 13 days
C. 24 days
Xenopozyme is primarily used to treat this rare, inherited condition, which affects the body’s ability to break down certain fats in cells
What is acid sphingomyelinase deficiency (ASMD)?
What are common side effects after the admin of actimmune and how can they be minimized?
Flu-like symptoms (fever, headache, chills, myalgia, fatigue).
Premedicate with acetaminophen and give at bedtime.
The frequency of a nulojix maintenance dose
Every 4 weeks
What is the lab produced protein that the Hympavzi drug is classified as, due to its ability to bind specifically to certain proteins in the body
Monoclonal antibody
The approval of Xenopozyme was supported by clinical trial results that demonstrated its effectiveness in improving this organ's function in patients with ASMD (which organ)
What is lung function?
What is the recommended frequency/intervals for labs (CBC, BMP, urinalysis) for patient on ACTIMMUNE therapy?
Prior to the beginning of treatment and at 3 month intervals during treatment.
Only patients that are seropositive for this virus should receive nulojix.
Epstein Barr Virus/ EBV
What is the protein that naturally prevents blood clots from forming by inhibiting the coagulation cascade. (This is the main target of Hympavzi)
Tissue factor pathway inhibitor (TFPI)
The pivotal clinical trials for Xenopozyme demonstrated improvement in the ability of patients to do this, which is often a measure of physical health
What is the ability to walk or motor skills?
What bacteria is Actimmune genetically engineered from?
A. E. COLI
B. SALMONELLA
C. MRSA
D. LISTERIA
The frequency of Nulojix infusions during the initial treatment phase
Day of transplant, 4 days, 2 weeks, 4 weeks, 8 weeks, 12 weeks after transplant
What is the bioavailability of Hympavzi after subcutaneous administration?
A. 55%
B. 99%
C. 71%
Like other enzyme replacement therapies, Xenopozyme helps to replace an enzyme that the body cannot produce in sufficient amounts due to a genetic mutation, which leads to this process
What is lysosomal storage disorder