Drugs
What is the brand name of Thalidomide?
Thalidomid
What are the common side effects of Thalidomide?
Drowsiness
Peripheral neuropathy
VTE
Constipation
What is the main counseling point for Thalidomide?
Use two forms of birth control.
What are the two indications for Thalidomide?
Erythema nodosum leprosum and Multiple myeloma
When should Thalidomide not be initiated?
Patients with and ANC <750/mm3
What is the brand name of Lenalidomide?
Revlimid
List 3 common and/or serious adverse side effects that may be caused by Lenalidomide?
1. Myelosuppression
2. VTE
3. Neuropathy
What time of day should Lenalidomide be taken?
Same time everyday.
List the common oncologic indication(s) of Lenalidomide:
Mantle Cell lymphoma
Multiple myeloma
Myelodysplastic syndromes
How does Lenalidomide differ from other drugs in this class?
Approved for maintenance therapy after autologous hematopoietic stem cell transplantation for multiple myeloma.
What is the brand name of Bortezomib?
Velcade
List 3 common and/or serious side effects that may be caused by Bortezomib?
1. Peripheral Neuropathy
2. Myelosupression
3. Herpes reactivation
When should subQ administration be considered for Bortezomib?
In patients with preexisting or at high risk for peripheral neuropathy.
List the common oncologic indication(s) of use for Bortezomib?
Mantle cell lymphoma
Multiple myeloma
How does Bortezomib differ from other drugs of the same class or family?
Used for newly diagnosed or relapsed/refractory multiple myeloma.
What is the brand name of Carfilzomib?
Kyprolis
List 5 common and/or serious side effects that may be caused by Carfilzomib.
N/V/D/C
Thrombocytopenia
Fatigue/Fever
Peripheral Edema
Anemia
What is the only way to give Carfilzomib?
IV infusion ONLY- Do not give as IV bolus
List the common oncologic indication(s) of use for Carfilzomib?
Multiple Myeloma
Relapsed or refractory
How does Carfilzomib differ from other drugs of the same class or family?
Once-weekly dosing option in combination with dexamethasone.