Medications
What is the prototype medication for viral entry blockers- CCR5?
Maraviroc
A client is taking Neucloside Reverse Transcriptase Inhibitors (NRTIs), what are some symptoms to report to provider?
Increase in fatigue, pallor, fever, onset of infection, constant nausea, vomiting, abdominal pain, diarrhea, headaches, insomnia, dizziness, fever, myalgia.
What is one of the four types of enzyme inhibitors for HIV?
nucleoside reverse transcriptase inhibitors (NRTIs)
non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Integrase inhibitors
Protease inhibitors (Pis)
What is the mechanism of action for Maraviroc (Viral Entry Blocker CCR5)?
Prevents HIV from entering lymphocytes by binding to CCR5 on cell membranes.
Which patients are at risk when taking Ritonavir, protease inhibitor (PIs)?
People with high blood sugar because it increases risk of diabetes.
What do you use to reconstitute Entry and Fusion inhibiting medications?
Sterile water
Upper respiratory infections (cough)
Which medication treats advanced HIV disease and is only used when there is resistance to other medications?
Entry and fusion inhibitors
Prototype: Enfuviride
What is the mechanism of action for Integrase inhibitors?
Block the HIV enzyme from inserting viral DNA into the host DNA. This stops HIV virus from replication.
What are the possible symptoms of an allergic reaction concerning Entry and Fusion inhibitors?
Chills, fever, rash, nausea, hypotension, and elevated liver enzymes.
What kind of testing should be done periodically for patients taking Non-nucleoside reverse transcriptase inhibitors (NNRTIs)?
Liver function test
How do you administer Zidovudine to a pregnant woman?
IV is given during labor until the neonate is delivered and the cord is clamped.
If pregnant – she will take zidovudine orally from 14 weeks to in labor
What is one mechanism of action for Entry and Fusion inhibitors?
To prevent HIV from shedding its protective coating and inserting the genetic material into the cell.
Clients need to look out for possible indications of liver injury, which includes what symptoms?
Itching of the skin, jaundice, any type of rash.
For individuals who are HIV positive, what type of medication therapy contributes to the prevention of AIDs and the reduction of HIV transmission?
Antiretroviral Therapy (ART)
What is a major adverse reaction for NRTIs?
Bone marrow suppression (shows up 2-4 weeks after starting treatment).
What is one key point about medication use that should be emphasized to clients living with HIV?
Medication adherence for the lifetime of client.