Innate Immunity
TLR3, RIG-I, and MDA5 all recognize this PAMP.
What is dsRNA?
These two isotypes can activate the complement cascade.
What are IgG and IgM?
These proteins recognize and cleave DNA adjacent to selected V, D, and J segments.
What are RAG1 and RAG2?
The founder of the Harvard Immunology PhD Program, Baruj Benacerraf, received the Nobel Prize for the discovery of genes encoding these molecules that the TCRs of CD8+ and CD4+ T cells recognize respectively.
What are MHC-I and MHC-II?
This process ensures that a B or T cell only expresses only one BCR or TCR despite carrying two genetic copies.
What is allelic exclusion?
Signaling downstream of TLR7 (an endosomal PRR that recognizes ssRNA) leads to the production of this cytokine.
What is IFN-I?
Anti-viral response
IgG is the only isotype capable of this effector function.
What is placental transfer OR opsonization OR antibody-dependent cellular cytotoxicity?
This enzyme generates junctional diversity between V, D, and J segments.
What is TdT?
TAP transports cytosolic peptides generated by this protein complex into the ER.
What is the proteasome?
MHC-I presentation pathway
A multivalent antigen, but not this, can trigger BCR cross-linking and the production of IgM.
What is a hapten?
T cell independent activation
Cleavage of this protein ultimately results in the release of mature IL-1B, IL-18, and IL-33 from the cell.
Pro-caspase-1
Pyroptosis
What is the polymeric immunoglobulin receptor (pIgR)?
Gene segment rearrangement occurs in this order on the Ig heavy chain and TCR beta chain.
What is D to J, then V to DJ?
Only V and J on Ig light chain and TCR alpha chain
This protein degrades upon entry to the lysosome, leaving behind CLIP.
What is the invariant chain?
MHC-II presentation pathway
B cells cannot undergo these two processes without the help of a T cell.
What are class-switching and affinity maturation?