History
Immune Cells
Innate Immunity
Primary Lit
Complement
100
Who visualized phagocytes at the site of injury and helped prove the concept of cellular immunity?
Who is Elie Metchnikoff
100
These granulocytes are known for their anti-parasite defense.
What are eosinophils?
100
Name at least 2 innate immune cells.
What are macrophages, neutrophils, eosinophils, basophils, mast cells, dendritic cells, or NK cells?
100
The technique, western blotting, involves separating proteins by what?
What is molecular weight?
What is molecular weight?
100
What is the initiator molecule for the classical pathway?
What is C1q
200
Edward Jenner observed that milkmaids who contracted cowpox were immune to smallpox. Immunity conferred in this instance occurred through what is known as ________
What is "the Cross-Protective Response"
200
The cluster of differentiation (CD) marker expressed on B cells is ______
What is "CD19"
What is "CD19"
200
This is a key protein in the TLR signal transduction pathway that, if knocked out, prevents most TLRs from inducing a response.
What is MyD88
200
RT-PCR is used to quantify the amount of what molecule?
What is RNA
200
C3a and C5a are uniquely known as _________
What are "anaphylatoxins"
300
Describe 3 differences between the innate and adaptive immune system?
Innate-Includes our first and second lines of defense, Activated in minutes to hours, Limited and fixed; Non-specific, Response remains the same overtime, Usually associated with myeloid lineage cells;
Adaptive-Third Line of Defense, Activated in 10-14 days, Highly diverse and specific, Becomes more robust with subsequent exposure, Usually associated with lymphoid lineage cells
300
What type of immune cell is this?
Neutrophil
300
What are two ways something can get phagocystosed?
1) PRRs located on phagocytes recognize PAMPS
2) Opsonin receptors located on immune cells recognize opsonin proteins that are bound to microbes
300
The knockout of which TLR led to the decreased expression of pro-inflammatory cytokines in SARS infected mice?
What is TLR2
300
C4b2a combine to form something known as __________. C4b2a3b combine to form something known as __________
What are C3 convertase and C5 convertase?
400
Which two researchers designed an experiment in the 1800's investigating whether cells or serum/plasma confers immunity?
Who are "Behring and Kitasato"
400
Name three markers that can be used to determine HSC's? Which stem cells are best for restoring bone marrow for humans? What about mice?
What is "c-kit and sca-1 for mice/murines; CD 34+ for humans"
400
Which PRRs recognize peptidoglycan and are responsible for activateding IL-1?
NOD1 and NOD2 (NLR family)
400
What is the function of oxPAPC utilized in figure 5 of the paper?
What is a TLR2 inhibitor
400
Name the three cells that contain the receptor CR1
What are phagocytes, RBCs, and B Cells.
500
Administering monoclonal antibodies to a patient is an example of?
What is "artificial passive immunity"
500
Describe one example of a model/disease where there is a defect in the thymus
Nude Mouse, DiGeorges syndrome, aging (thymus gets smaller)
500
Dermcidin and Histatin both possess antifungal properties but are located in different parts of the body. Dermcidin is located in _________ whereas histatin is found in ____________. Which one also possesses antibacterial properties
What are "sweat glands" and "salivary glands"? What is dermcidin?
500
In Figure 4a, the researchers use _______ to indicate CD45+ cell death as a result of severe inflammation.
TUNEL staining
500
For the alternative pathway, what is the other name for C3 Convertase (name that shows the subunits)
What is C3bBb