Baby B-Cells
This organ was how the B-cells were discovered.
What is the bursa of Fabricus?
The expression of CD19 begins here.
What is the progenitor B-cell (pro-B-cell)?
This is where the B-cell reaches maturity.
What is the spleen?
This method of B-cell activation involves peptides in MHC class II molecules.
What is T-dependent activation?
I am on all nucleated cells.
What is MHC class I?
B-cells are born here.
What is the bone marrow?
IgM is expressed at this stage of development.
What is the immature B-cell?
This is the process by which BCRs are tested for self-recognition before being released into circulation.
What is negative selection?
This is a specialized place in the lymph node where several events occur for the proliferation of B-cells.
What is the germinal center?
You can mostly find me on APCs.
What is MHC class II?
This self-renewing cell is the mother of all cells, including B-cells.
What is the hematopoietic stem cell?
During B-cell development, this process occurs if the BCR fails the test and is reactive to self, but can study and take the test again.
What is receptor editing?
What is light chain gene rearrangement?
I only express CD27.
What are plasma cells?
What are memory B-cells?
Polysaccharides on the surfaces of bacteria and fungi are an example of these.
What are T-independent antigens?
I process exogenous antigens.
What is MHC Class II?
This cell gives rise to the T-cells and the B-cells.
What is the common lymphoid progenitor (CLP)?
This stage is where the first immunoglobulin gene rearrangement takes place.
What is the progenitor B-cell (pro-B-cell)?
This differentiated cell is "on patrol."
What is the memory B-cell?
This enzyme is responsible for somatic hypermutation (SMH).
What is activation-induced cytidine deaminase (AID)?
During this process APCs can process and present exogenous antigens to CD8+ T-cells.
What is cross presentation?
(exogenous Ags are usually presented to CD4+ T-cells)
The non-lymphoid cells populate the microenvironment/niche of the bone marrow and assist with B-cell development.
What are stromal cells?
This is stage where allelic exclusion takes place for the heavy and light chain.
What is the precursor B-cell (pre-B-cell)?
These cells have survived negative selection, but remain in the bone marrow for 24 more hours before migrating to the spleen.
What are transitional B-cells?
I am a co-stimulator molecule on B-cells and I am important in helping the B-cell undergo SMH and class switching.
What is CD40?
Antigens are processed through a proteasome to make peptides for this MHC.
What is MHC Class I?