Immunology
Hogwarts
Justin Bieber
Cats
Potpourri
100
This class of immunoglobulin is first to be secreted and first to appear on B cells.
What is IgM?
100
Cytokine signaling generally proceeds through this pathway.
What is JAK/STAT?
100
This type of protein stimulates the inflammatory state due to an infection.
What are cytokines/ chemokines?
100
These cell surface proteins allow leukocytes to adhere to blood vessel walls.
What are integrins?
100
This is a modulator protein that binds with calcium to initiate a kinase cascade that promotes T-cell signaling.
What is calmodulin?
200
A type 1 reaction is known commonly as "allergies", but it should be called this reaction.
What is hypersensitivity?
200
Immunosuppression resulting from stimulated T cells proliferating and rapidly undergoing apoptosis occurs during this syndrome.
What is toxic shock syndrome?
200
These are the three mechanisms of adaptive immunity.
What is neutralization, opsonization, and complement activation?
200
This pokes holes in target cell's cell membrane so that granules' contents can enter the target cell.
What is perforin?
200
This is when antibodies bind pathogens or products, preventing them from entering cells.
What is neutralization?
300
These are three functions of a pathogen used to avoid elimination by the immune response.
What is antigenic variation, latency, resistance to immune effector mechanisms or suppression of immune response?
300
This is a major co-receptor involved in HIV binding to CD4 T cells, dendritic cells, and macrophages.
What is CCR5/CCR4?
300
Affinity maturation occurs here.
What is the lymph node or the germinal center?
300
This is when pathogens and foreign particles are coated with antibodies that can be recognized by phagocytes.
What is opsonization?
300
These immunoglobulins are responsible for the hypersensitivity reaction.
What is IgEs?
400
This is a treatment for graft vs. host disease in a hematopoietic stem cell transplantation.
What is depleting mature T cells from the graft?
400
This is a similarity between antibodies and gamma:delta T cell receptors.
What is being able to bind free antigens, without any processing?
400
This is when pathogens and foreign particles are coated with antibodies that activate a system of proteins used to attract macrophages and rupture cell membranes.
What is complement activation?
400
This subset of helper T cells is most effective in augmenting immune responses to extracellular bacteria and fungi.
What is Th17?
400
This nucleotide sequence determines which V-region gene segments recombine together.
What is 12 or 23 nucleotide spacer?
500
An individual with X-linked SCID would have stunted development of these cells.
What is T cells and NK cells?
500
This is the reason why plasmodium, the parasite that causes malaria, are sometimes able to go undetected in red blood cells.
What is the red blood cells are non-nucleated and do not contain MHC class I, which is needed to mediate T lymphocyte activity and thus adaptive immunity?
500
If an H-2s mouse is irradiated and given a bone marrow transplant with bone marrow from a H-2sxq mouse and allowed to recover, the T cells in the animal will respond to this type of MHC.
What are H-2s and H-2 dxs?
500
This determines whether a cell will be positively or negatively selected.
What is the strength of the signal it receives?
500
MHC polymorphisms tend to cluster here.
What is in the peptide binding groove?
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