Serology
Big H
High Five!
Carrying the Torch
An ounce for a pound...
100
CMV IgM remains positive for this length of time after infection.
What is 12-18 months?
100
A positive Hepatitis B surface antigen result should prompt which additional testing?
What are HbcAb, HbsAb, HbeAg, HBV viral load, and LFTs?
100
Cesarean Delivery should be considered for patients with a viral load greater than this value.
What is 1000?
100
Infection with Rubella is most likely to cause congenital infection during this time period.
What is 0-12 weeks? In this time frame, there is a 100% risk of congenital infection resulting in major anomalies. From 13-16 weeks, Deafness and retinopathy occur in 15%. After 16 weeks, there is a slight risk of deafness and retinopathy.
100
Either of these medications can be used to decrease HSV lesions or shedding around the time of delivery.
What are Acyclovir 400 mg tid, or Valacyclovir 500 mg bid?
200
History of these activities should prompt testing for Hepatitis C.
What is any IV drug use, Hx HIV, persistently abnormal LFTs, hx long term hemodialysis, Hx transfusion or transplantation prior to 1992, Hx of clotting factor concentrates before 1987, Hx of exposure, Hx of incarceration.
200
The antibody found in serum of patients immune to Hepatitis due to vaccination.
What is anti Hepatitis B surface antibody?
200
The CDC recommends routine HIV screening for this population of pregnant women.
Who are all pregnant women?
200
Patients should receive this vaccine prior to hospital discharge and 4-6 weeks postpartum if they have no history of chickenpox, or prior immunization.
What is Varivax?
200
For patients exposed to Varicella in pregnancy, this may be used as varicella prophylaxis.
What is VariZIG?
300
40 to 50% of adults demonstrate positive serology to this organism, and close to 80% in Parisians. A reference laboratory should be consulted to determine if a patient truly has a new infection.
What is Toxoplasmosis? Serology suggesting a new infection includes IgM specific antibody, extremely high IgG titer, or documentation of IgG seroconversion from negative to positive.
300
Passive vaccination with HBIG should be given to an infant within this time period.
What is 12 hours?
300
Screening for this antigen can allow earlier detection of infection than traditional antibody based assays.
What is p24?
300
This is in the differential of a fetus with a sinusoidal pattern of fetal heart tracing.
What is aplastic anemia due to Parvovirus B19 infection?
300
While passive and active immunization for this condition are acceptable options, antiviral therapy can be considered with high viral load of this condition.
What is Hepatitis B?
400
Avidity testing may assist in elucidating timing of this infection.
What is CMV? IgG avidity increases with duration of time since infection.
400
The percentage of infants infected via maternal to child transmission of Hepatitis B without prophylaxis?
What is 90%? This risk is reduced to 5-10% with prophylaxis. 90% of infants infected at birth will become chronic carriers.
400
HIV infection is a contraindication to breastfeeding, except for this situation.
What is in areas with contaminated water, where risk of death from diarrheal diseases outweighs the risk of HIV infection?
400
The most common congenital viral infection.
What is CMV? 40% of primary infections result in mother to child transmission, but only 2% of recurrent infections result in transmission.
400
Screening for this STD should be by history only, unless your patient's partner has a known infection.
What is HSV?
500
Women with this finding following exposure to Parvovirus should have repeat serology in 3 weeks.
What is negative IgG? If the patient is IgG positive-no further evaluation is necessary.
500
This antigen is particularly correlated with a high level of infectiousness.
What is Hep B E antigen?
500
Coinfection with HIV increases risk for transmission of this virus from 3-5% to 20%.
What is Hepatitis C?
500
Genital lesions or prodromal symptoms of this infection should prompt cesarean delivery.
What is genital Herpes? Risk of maternal to child transmission is 40-60% if primary infection around time of delivery, but decreases to 1-3% with a recurrent episode.
500
In conjunction with a specialist in infectious diseases, treatment of maternal HIV infection should be continued or started with HAART therapy, including this combination of antivirals.
What are at least three drugs from two classes. Classes of antivirals include NRTI's, NNRTI's and protease inhibitors.
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