streptococcal
staphylococcal
enterococcus
HACEK
pseudomomonas
100
antibiotics for native valve strep endocarditis with mic <0.12?
pen G 4 weeks ceftriaxone 4 weeks penG + gent 2 weeks together ceftriaxone + gent 2 weeks together
100
native valve MSSA?
nafcillin/oxacillin + gent 6 weeks stop gent after 3-5 days cefazolin + gent for 6 weeks. stop gent after 3-5 days
100
for native and prosthetic valve susc to pen gent and vanc ?
amp + gent 4-6 weeks penG + gent 4-6 weeks vanc + gent 6 weeks
100
HACEK native valve?
ceftriaxone, ampicillin/sulbactam, ciprofloxacin they are all for 4 weeks cipro has some resistance issues so use if there are probs with the other choices.
100
pseudomonas
tobramycin piperacillin cefepime ceftazidime for 6 weeks
200
antibiotics for native valve strep mic <0.12mcg/ml? in case of allergies to penG
Vancomycin for 4 weeks
200
native valve MRSA?
daptomycin or vancomycin both for 6 weeks
200
native and prosthetic susc to vanc and pcn but resistant to gent?
amp + strep 4-6 weeks penG + strep 4-6 weeks vanc + strep 6 weeks
200
prosthetic valve HACEK
ceftriaxone, ampicillin/sulbactam, ciprofloxacin they are all for 6 weeks in this case cipro has some resistance issues so use if there are probs with the other choices.
300
when can you consider 2 week therapy with native valve endocarditis/
No vegetation > 5mm crcl> 20 clinical response within 7 days no thromboembolic disease no cardiovascular risk factors
300
prosthetic valve MSSA?
nafcillin/oxacillin +rifampin + gent do for > 6 weeks and stop gent at 2 weeks
300
native and prosthetic ssc to vanc and gent but resistant to penicillin
amp/sulbactam + gent for 6 weeks vanc + genta for 6 weeks
300
funghi
amphotericin + flucytosine( bone toxicity) fluconazole for life. surgery to remove valve.
300
for IE prevention/prophylaxis?
amox, clinda, azithromycin, clarithromycin cefazolin or ceftriaxone IV/IM
400
native valve PCN 0.12-0.5 what drugs do you use?
penG + gent 4 weeks stop gent after first 2 weeks ceftriaxone + gent 4 weeks stop gent after 2 weeks vancomycin 4 weeks
400
prosthetic valve MRSA?
vanc + rifampicin+ genta for > 6 weeks ad stop geta at 2 weeks
400
e faecalis resistant to vanc, penicillin and aminoglycosides?
imipenem/cilastatin + ampicillin > 8 weeks ceftriaxone + ampicillin> 8 weeks
400
cv device infection? like pacemaker
2 blood tests vanc+ rifampin 10-14 days after device removal 4-6 weeks if Infectious endocarditis on leads new device after 72 hours neg for leads and 14 days from first negative for valve vegetation.
400
culture negative infectious endocarditis Native valve?
amp/sul + gent for 4-6 weeks or vanc+ gent + cipro 4-6 weeks
500
prosthetic valve PCN < 0.12
penG+ Gent 6 weeks stop gent after 2weeks ceftriaxone + gent 6 weeks stop gent after 2 weeks vancomycin for 6 weeks for MIC > 0.12 do the same drugs but everything including gent for 6 weeks.
500
IVDU uncomplicated
nafacillin/oxacillin + genta for 2 weeks stop geta after 3-5 days cefazolin + genta for 2 weeks stop genta after 3-5 days for native MRSA IVDU use daptomycin or vancomycin for 4-6 weeks
500
e faiecium
daptomycin, linezolid, synercid all for more than 8 weeks
500
negative IE prosthetic valve > 1 year out
amp/sul+genta+rifa for 6 weeks or vanc+genta+cipro+rifampin for 6 weeks
500
prosthetic valve negative IE? prosthetic valve < 1 year
vanc + cefepime+ rifampin+gentamycin for 6 weeks. stop gent at 2 weeks.
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