Overview 1
When immunity and inflammation are working well, a person is said to be
Immunocompetent
Cell surface proteins are non-self to another person except for
an identical twin
Another name for inflammation is
natural immunity, or innate immunity
Neutrophils make up what percent of the total WBC count
55-70%
Mature neutrophils are the only stage capable of
phagocytosis
Name at least 3 body defenses to prevent organisms from entering the body
intact skin, mucous membranes, skin surface normal flora, natural chemicals that inhibit bacterial growth
Cell surface proteins are non-self to another person so they are called
antigens
True or false: Inflammation is a type of immunity than can be transferred to another person
False
Another name for mature neutrophils is
Segmented (segs), or polymophonuclear cells (polys)
What is an absolute neutrophil count
percentage of actual number of mature circulating neutrophils
Name at least 2 non-self proteins or cells
cancer cells, cells from another person, invading organisms
How many major HLA's can each persons genes express
6
Inflammation occurs sometimes with an infection. Name 3 examples
Otitis Media, appendicitis, viral hepatitis, cholecystitis, local infections etc
Some neutrophils are called "bands" because
They are immature
What is a differential WBC count?
Number and percent of the different types of circulating leukocytes
These are the only cells capable of determining self from non self
Immune system cells
Name 4 reasons a persons immunity can change over their lifetime
nutrition, environmental conditions, drugs, disease and age
Inflammation can occur without an infection. Name 3 examples
Sprains, MI, blister, allergies, contact dermatitis etc
Growth factors can decrease the time needed for the growth of a stem cell to full maturation from 12-14 days to
hours
What is a "left shift"
When the "bands" are more numerous than the segs
Unique surface cell proteins are called
Human leukocyte antigens (HLA's)
Stem cells are called pluripotent because
each one has more than on potential outcome
Name the cell types that are involved in inflammation
neutrophils, macrophages, eosinophils, and basophils, Also, mast cells
What is the normal lifespan of a neutrophil
12-18 hours
What is the normal % of bands on a differential WBC?
5%