Historical Figures
This scientist developed a smallpox vaccine in 1798 by inoculating an 8-year-old boy with cowpox
Who is Edward Jenner?
This cell type originates in the bone marrow and develops in the thymus
What are T cells?
The antibody light chain does not contain this segment
What is D (Diversity)?
These activation pathways generate C3b
What are Classical, Lectin, and Alternative?
Dendritic cells are part of this immune response
What are innate and adaptive?
Louis Pasteur injected chickens with this to create an attenuated vaccine
This T cell subtype recognizes MHC Class II
What is T helper cell (CD4+)?
This chain includes VJ and C segments
What is the kappa light chain?
This pathway starts out with C3 (H2O)
What is the Alternative Pathway?
Passive immunity
These dogs were responsible for the Great Serum Run of 1925
Who are Togo & Balto?
These are Ig-secreting cells
What are plasma cells?
This complex is necessary for recombination to occur
What is RAG1/2?
This is exposed when C4 is cleaved in the Classical Pathway
ALRs, CLRs, TLRs, NLRs, and RLRs are all this type of innate immune receptor
What are PRRs (Pattern Recognition Receptors)?
This scientist demonstrated the presence of two types of lymphocytes in chickens
Who is Bruce Glick?
CD28 and ICOS facilitate activation of this cell type
What are T cells?
TdT (terminal deoxynucleotidyl transferase) is responsible for adding these nucleotides during VDJ recombination
What are nontemplated nucleotides?
C4b2a3b is the C5 convertase in these two pathways
What are Classical and Lectin?
This cell type looks for missing MHC-I molecules on cell surfaces
What are NK cells?
Susumu Tonegawa was awarded the Nobel Prize in Physiology or Medicine in 1987 for his discovery of this
What is V(D)J recombination?
Antigen binding, CD40 costimulation, and cytokine signaling are steps in which process
What is T-dependent B cell activation?
This states that an RSS containing a 12-bp spacer must pair with an RSS containing a 23-bp spacer
What is the 12/23 Rule?
This component of the MAC creates a small pore in the target membrane
What is C8?
This antibody isotype is best at fixing complement