Introduction to Chemotherapy

MOA

100

Cause cellular damage by platinum binding to DNA and formation of intrastrand cross-links (Name of a drug)

What is Cisplatin (Patinol) Carboplatin (Paraplatin) Oxaliplatin (Eloxatin)

200

Inhibitor of dihydrofolate reductase (DHFR) resulting in depletion of intracellular pools of reduced folates essential for thymidylate and purine synthesis (Name of a drug)

What is Methotrexate (Folex) Pemetrexed (Alimta)

300

Binds to tubulin, the structural protein that polymerizes to from microtubules, and inhibits the assembly of microtubules (Name of a drug)

What is Vinblastine (Velban) Vincristine (Oncovin) Vinorelbine (Navelbine)

400

Inhibits topoisomerase II, producing double-strand breaks (Name a drug)

What is Etoposide (VP‐16, Vepesid) Tenoposide (VM‐26, Vumon) Daunorubicin hydrochloride (Cerubidine) Doxorubicin hydrochloride (Adriamycin) Idarubicin (Idamycin) Epirubicin (Ellence) Mitoxantrone (Novantrone)

500

Inhibits thymidilate synthase (Name of a drug)

What is Fluorouracil (5‐FU, Adrucil) Capecitabine (Xeloda)

Toxicities

100

Which of the following drugs can causes hemorrhagic cystitis? a. Methotrexate b. Doxorubicin c. Rituximab d. Cyclophosphamide

What is d. Cyclophosphamide (Ifosfamide also does)

200

Name ONE common toxicity of antifolates?

What is Dose limiting leukopenia and thrombocytopenia (esp Pemetrexed with neutropenic sepsis) Renal tubular necrosis (high dose methotrexat) Pulmonary pneumonitis Alopecia Stomatitis and mucositis

300

Which of the following has a black box warning emphasizing the need for prophylaxis of opportunistic infections during treatment? a. Etoposide b. Rituximab c. Alemtuzumab d. Vinorelebine

What is c. Alemtuzumab

400

Which of the following is NOT associated with vincristine administration? a. Fatal if given intrathecal b. Dose-limiting myelosuppression c. Dose limiting neurotoxicity d. Dose limiting constipation and paralytic ileus

What is b. Dose-limiting myelosuppression

500

Name ONE common toxicity of rituximab.

What is Infusion related reactions (fever, chills/rigors, hypotension, nausea)‐Premedicate Tumor lysis syndrome Mucocutaneous reactions Hepatitis B reactivation Progressive Multifocal Leukoencephalopathy (PML)

Targeted Therapy

100

Recombinant humanized MoAb directed against CD52 antigen present on leukemic lyphocytes in CLL

What is Alemtuzumab

200

Name of the recombinant humanized MoAB selectively binds to HER-2.

What is Trastuzumab (Herceptin)

300

Selective inhibitors of tyrosine kinase activity of BCR-ABL fusion gene, resulting in apoptosis of BCR-ABL positive cells (Name of a drug)

What is Imatinib mesylate (Gleevec) Dasatinib (Sprycel) Nilotinib (Tasigna)

400

Name TWO common adverse effects of Bevacizumab.

What is Hypertension Bleeding episodes and thrombotic events Black-box warning for GI perforation

500

Chimeric MoAB directed against _______ found on the surface of normal and malignant __ cells (Fill in the blanks)

What is Chimeric MoAB directed against CD20 found on the surface of normal and malignant B cells

Brand/Generic

100

Alimta

What is Pemetrexed

200

Herceptin

What is Trastuzumab

300

Avastin

What is Bevacizumab

400

Velcade

What is Bortezomib

500

Xeloda

What is Capecitabine

Misc

100

What chemotherapeutic agent turns urine red? a. Doxorubicin b. Methotrexate c. Temzolomide d. Busulfan

What is a. Doxorubicin

200

The antidote for extravasation of anthracyclines is?

What is DMSO or Dexrazoxane (Totect) -Also apply a COLD compress-

300

Name a drug that can cause hand‐foot syndrome?

What is Fluorouracil (5FU) and Capecitabine

400

Name of the drug that causes infusion related hypotension if adminstered to rapidly.

What is Etoposide (VP‐16, Vepesid)

500

Explain the mechanism of crizotinib.

What is inhibitors binding of ATP to the intracellular domain of activated ALK (EML4‐ALK fusion oncogene). This inhibits phosphorylation and subsequent activation of the RAS pathway.