Abbrv.
MALDESI
What is Matrix-Assisted Laser Desorption Electrospray Ionization
For the analysis of complex glycopeptides in proteomics, this ionization technique is preferred due to its ability to handle large, labile molecules and its compatibility with aqueous buffers.
What is Electrospray Ionization (ESI)
The third harmonic wavelength of an Nd:YAG laser.
What is 355nm
These two individuals won the Nobel Prize in Chemistry for ESI and MALDI in 2002.
Who is John B. Fenn and Koichi Tanaka
An ionization technique used to enhance the ionization efficiency of neutral molecules.
What is MALDI-2
APCI
What is Atmospheric Pressure Chemical Ionization
Type of molecule that is commonly detected as a multiply charged ion when using ESI
What are peptides/proteins?
An instrument modification to improve spatial resolution sub 1 micron.
What is transmission geometry
DAILY DOUBLE: Developed a handheld mass spectromtry device that can be taken into surgery for the analysis of biomolecules.
Who is Livia Eberlin
FAB
What is Fast Atom Bombardment
This difference in the energy imparted to the analyte distinguishes ionization techniques like Electron Ionization (EI) from ionization techniques like MALDI, resulting in either fragmentation or intact ions.
What is hot and cold ionization?
In electrospray ionization, this structure forms at the tip of the capillary.
What is a Taylor Cone
The scientist most often credited as the pioneer of imaging mass spectrometry.
Who is Richard Caprioli
This technique combines laser-induced ablation with ionization to do elemental and stable isotope analysis of solid samples without requiring sample preparation.
What is LA-ICP (Laser Ablation Inductively Coupled Plasma)
AP-SMALDI
What is Atmospheric Pressure Scanning Microprobe Matrix-Assisted Laser Desorption/Ionization
A commonly accepted MALDI mechanism.
AHnn++nX- ---> AH++X-+n-1HX
What is the lucky survivor model
A commonly used matrix for MALDESI experiments due to its ability to absorb infared wavelengths.
What is water
Who is JJ Thompson
What is electron impact
SICRIT
What is Soft Ionization by Chemical Reaction In Transfer
The difference in laser beam angle as it approaches the sample surface on a timsTOF fleX versus an AP-SMALDI system.
What is angled versus orthogonal
This reagent is used in mass spectrometry for derivatizing aldehydes and ketones to promote the ionization of molecules.
What is Girard's Reagent T or P
The 1997 winners of the American Society for Mass Spectrometry Distinguished Contribution in Mass Spectrometry award for their development of MALDI as we use it today.
Who are Franz Hillenkamp and Michael Karas
This ionization technique involves the bombardment of the sample with a primary ion beam to glean information about the sample surface.
What is SIMS (Secondary Ionization Mass Spectrometry)