Absorption
Where is iron mainly absorbed?
Small intestine - duodenum
What molecule transports iron in the bloodstream?
Transferrin
Where is iron mainly stored?
Liver (parenchymal cells)
Which has more Iron, 85g of oysters or 85g of beef liver?
Oyesters - 8mg vs 5mg
Which Iron ion is more readily absorbed from the lumen of the small intestine?
Fe2+
How many Fe3+ does 1 transferrin molecule bind?
2
What is the main iron storage molecule?
Ferritin
Name a genetic factor that would influence iron dietary intake recommendation
Heamachromatosis
What enzyme converts Fe3+ to Fe2+ so that it can enter enterocytes (duodenal cells)
Vitamin C Ferrireductase / Duodenal Cytochrome B
What is transferrin that is non iron bound called?
Apo-transferrin
Which cell does ~75% of absorbed iron end up in?
Erythroblasts
Name a vitamin deficiency that would lead to decreased iron absorption
Vitamin A and riboflavin
How does Fe2+ go from basal side of small intestine cell to the bloodstream?
Ferroportin transporter
What organ produces and secretes apo-trasferrin?
Liver
Roughly what % more iron would a woman in her 30s need compared to a man in his 30s
50%
Which transporter does Fe2+ go through on the apical surface of duodenal cells and what is co-transported?
DMT-1 (divalent metal transporter) with H+
What peptide hormone reduces the amount of iron in the blood, how?
Hepcidin - inhibit ferroportin
When there is more iron than available ferritin, what complex is formed?
Hemosiderin
Name a food that has 100% of your Iron DV
Breakfast cereal fortified with 100% of iron DV