Trokendi XR
Over the last 2-4 years, several companies have launched a monoclonal antibody migraine treatment that targets _____.
Calcitonin gene-related peptides
Half of all migraine sufferers have their first attack before ______ years of age.
12
In the North American subset of data, Oxtellar XR was statistically significant compared to placebo for:
1200 mg and 2400 mg
What are the chemical messengers of the brain?
Neurotransmitters
A list of plan approved drugs that encourage physicians to prescribe cost-effective treatments is referred to as a(n)_________.
Formulary
______ are medications designed to help relieve nausea and vomiting.
Antiemetics
______ treatment is aimed at aborting a headache or catching it early in its course to prevent progression and provide relief within a 2-hour period.
Acute
A drug’s half-life depends on which of the following:
A) Volume of distribution
B) Plasma clearance
C) How often it is administered
D) Both A and B
D) Both A and B
No cause for seizures can be found in about ____ of people with epilepsy.
70%
What pregnancy category is topiramate?
D
A(n) ______ is used at home when other treatments fail, and permits the patient to achieve relief without the discomfort and expense of a visit to the physician's office or emergency department.
Rescue medications
Triptans can lead to medication overuse headache (MOH) and should not be used more than _____ days weekly on a chronic basis.
2-3
_______ is the determination of which of the two or more diseases with similar symptoms is the one from which the patient is suffering, by comparing and contrasting the clinical findings.
Differential diagnosis
Which of the following is considered the most important tool in diagnosing epilepsy?
Medical history
The area under the curve (AUC) reflects the total amount of a drug that is:
Absorbed by the body
Information regarding Trokendi XR’s dosage and use in conjunction with alcohol can be found in all of the following places in the PI, EXCEPT:
A) Contraindications
B) Non-Clinical Toxicology
C) Warnings and Precautions
D) Dosing and Administration
B) Non-Clinical Toxicology
A full therapeutic trial of preventive migraine medication may take _____ months before the maximum treatment response is evident.
2-6
Which of the following is not one of the 6 Principles of Pharmacologic Treatment?
A) Keep the regimen as simple as possible
B) Counsel the patient to be sure he/she follows the drug regimen
C) Try at least three monotherapy options before attempting polytherapy
D) All of these are included in the 6 Principles of Pharmacologic Treatment
C) Try at least three monotherapy options before attempting polytherapy
Which is more important for a patient with epilepsy: Onset of Action or Duration of Action?
Duration of Action
What is the primary tool for diagnosing migraine?
Medical history
What dosage strengths of Topiramate were administered to patients in the Phase 1 103 bio-availability study?
100mg BID of Topamax v. 200mg QD of Trokendi XR
True or False. Most migraine patients do not require diagnostics testing to receive a migraine diagnosis.
True
Bioavailability can be best described as the:
The fraction of administered drug that reaches the circulation and exerts its effects
Which of the following selections lists the steps in differential diagnosis in order?
A) Neuroimaging, Clinical Evaluation, General Lab Tests, Neurophysiological, Other
B) General Lab Tests, Clinical Evaluation, Neuroimaging, Neurophysiological, Other
C) Clinical Evaluation, General Lab Tests, Neurophysiological, Neuroimaging, Other
D) General Lab Tests, Neuroimaging, Clinical Evaluation, Neurophysiological, Other
C) Clinical Evaluation, General Lab Tests, Neurophysiological, Neuroimaging, Other
Which of the following is true about the PI? Select all that apply.
A) It is FDA- approved and based on NDA (New Drug Application) data
B) The drug manufacturer can update information with new data
C) PI language supports ALL product conversations
D) PI is included on ALL promotional material given to HCPs
A) It is FDA- approved and based on NDA (New Drug Application) data
C) PI language supports ALL product conversations
D) PI is included on ALL promotional material given to HCPs