M & M
Cibinqo is highly selective for this JAK kinase?
What is JAK 1?
What is Lit-foo-loo?
This DB placebo controlled trial was a key pivotal trial in attaining our indication.
What is JADE MONO or JADE Compare?
Instead of percentages, we used this measurement of time for safety
What are patient years?
This cytokine is prominent during Chronic AD and contributes to barrier defect
What is IL-22?
Where the site of inhibition for JAK inhibitors takes place
What is the ATP binding pocket?
The inclusion of TEC kinases makes Litfulo what type of inhibitor?
What is a kinase inhibitor?
Our long-term data was observed for this amount of weeks
What is 96 weeks?
This lab is not required for Lit initiation
What is lipid testing?
This cytokine promotes itch and is secreted by keratinocytes
What is TSLP?
Cytokine specific monoclonal antibodies, receptor specific monoclonal antibodies, and JAKi are all agents involved in the interruption of cytokine . . .
What is signal transduction?
Any of these factors increases the AA severity rating
What are . . .
eyebrow/eyelash involvement
negative impact on psychosocial function
positive hair-pull test
inadequate response after greater than 6 months
The data represented for our 24-hour itch data is this type of analysis
What is least square means (LSM)?
This study in another JAK inhibitor led to the boxed warning for the class of JAK inhibitors
What is Oral Surveillance?
At 24wk in the ALLEGRO study, the total number of serious infections, malignancies, VTE’s and opportunistic infections multidermatomal herpes zoster totaled what number?
What is 0?
These agents interrupt cytokine signal transduction and work inside the cell as small molecules
These are key cytokines that drive disease progression in Alopecia Areata
What are IL-15 & IFNG?
These key inflammatory cytokines signal through JAK 1 and are important in AD
What are IL-4, IL-13, IL-31, IL-22, TSLP & IFN gamma?
You may have this and not know it, so you have to run labs to catch it
What is latent TB?
These arms of the pivotal trials were eligible to enroll in the Allegro Long-Term study?
What is Allegro 2A Safety, Allegro 2A, Allegro 2B/3?
These kinases are activated or phosphorylated downstream of JAK pairing
What is STAT?
The mean SALT score for non AT/AU patients in the Litfulo pivotal trials
What is SALT 82?
This clinical study observed incidence rates in MACE, Malignancies & VTE's for patients being treated for AD (excluding JAK inhibitors)
What is the Cohort Data?
Look out for these 2 invasive fungal infections (they're hard to catch & even more difficult to pronounce)
What are cryptococcosis & pneumocystosis?
This family of Kinases are primarily expressed in hematopoietic cells and play a role in T & B cell antigen receptor signaling
What is TEC Family Kinases?