Pattern Recognition Receptors
Antibody
Migration
Immune Deficiency
Basics
100

These cytosolic pattern recognition receptors detect viral RNA and signal through the mitochondrial adaptor MAVS to induce type I interferon production.

What are RIG-I-like receptors (RLRs)?

100
This antibody isotype is found as a dimer in its secreted form
What is IgA?
100
Initial low-affinity binding of leukocytes by these proteins.
What are selectins?
100
A defect in this protein is the most common cause of CGD
What is gp91?
100
Characteristics of the adaptive immune system.
What are specificity, diversity, and memory?
200

This family has a distinct structure with a C-terminal leucine-rich repeat domain that senses the presence of ligand, a central NACHT domain leads to oligimerization, and an N-terminal effector domain which recruits other proteins to form signaling complexes.

What are NOD-like receptors (NLRs)?

200
These are the two types of immunoglobulin light chains.
What are kappa and lambda?
200
Protein that mediates tight adhesion of cells prior to diapedesis
What are integrins?
200
What is the most common cause of Class I deficiency?
Defects in TAP proteins.
200
The gut-associated lymphoid tissue located at the beginning of the colon
What is the appendix?
300

This cytosolic pathway uses cGAS to produce cGAMP after recognizing double-stranded DNA, leading to the production of type I interferons.

What is STING?

300
This leads to IgG having the longest half-life.
What is binding of the IgG Fc region to the neonatal Fc receptor?
300
Downregulation of this receptor causes T cells to stay in the lymph node.
What is sphingosine-1-phosphate receptor?
300
Causes delayed umbilical cord separation.
What is LAD-1?
300
The theory that antigen-specific clones of lymphocytes develop before and and independent of exposure to antigen.
What is the clonal selection theory?
400

This C-type lectin receptor recognizes β-glucans in fungal cell walls and signals through SYK and CARD9 to promote antifungal immune responses.

What is dectin-1?

400
The average kappa:lamda in humans is?
What is 2:1?
400
This must be activated for cells to bind tightly.
What is ICAM or integrins?
400
The disease caused by T cell deficiency due to lack of thymus.
What is DiGeorge?
400
The MHC is located on this chromosome in humans.
What is chromosome 6?
500

Gain-of-function variants in this gene cause cryopyrin-associated periodic syndromes, including familial cold autoinflammatory syndrome, Muckle–Wells syndrome, and NOMID.

What is NLRP3?

500
This is the most variable region in antibody.
What is CDR3?
500
Homing to the gut is mediated by this selectin and receptor.
What is MadCAM-1 and alpha-4/beta-7?
500
Deficiency in this leads to HSV encephalitis
What is TLR3 or UNC9381?
500
The professional APCs.
What are dendritic cells, macrophages, and B cells?
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