Janumet Efficacy
How much does Janumet decrease A1c from a baseline of 11%?
3.6%
What patient catergory did the TECOS trial include?
Cardiovascular Disease patients
What is the inhibition rate of Janumet on the DPP4 enzyme?
97%
How safe and effective is Janumet in Elderly patients (>65 yo)
Safety and effectiveness of Januvia in elderly were comparable to those seen in younger patients
What were the 2 study arms of the Composit-R study?
Dapagliflozin 10mg and Januvia 100 mg
In what stages of diabetes is Janumet the most effective?
All stages, but the highest A1c drop is in newly diagnosed patients
What is the median duration of diabetes in the patients included in the TECOS study?
11.6 years
What is the only DPP4i that has a high selectivity on the DPP4 enzyme?
Sitagliptin
In which renal impairment populations is sitagliptin studied?
Mild, moderate, severe and end stage on dialysis
What was the difference in the A1c reduction?
0.15%
What is the most studied DPP4?
Sitagliptin
In the TECOS trial, sub-analyses were published for which patient category?
Renally impaired patients, Heart failure patients, Elderly and fracture risks
What is the difference in the A1c reduction between Januvia and Vildagliptin?2-
20%
What is the new renal adjustment needed for Januvia?
GFR >50 mL/min = 100 mg daily
GFR >30 mL/min to <50 mL/min = 50 mg daily
GFR<30 mL/min =25 mg daily
What is the propotion of patients who achieved HbA1c <7% in the 2 arms?
Januvia 43%
Dapagliflozin 27%
What did the Odyssee study show?
Less hypoglycemia, less body weight change, patients maintained treatment longer (almost 2 years longer)
What did TECOS trial show regarding Pancreatitis and Pancreatic cancer
Both uncommon
What is the inhibition rate of Linagliptin, saxagliptin and allogliptin on the DPP4 enzyme?
80%
What do you think are the advantages of keeping or giving sitagliptin if you want to initiate insulin in your type 2 diabetic patient?
Less hypoglycemia, lower dose of insulin required and more A1c control
What population was studied in the Composit R trial?
Mild renally impaired patients with more than 25 years of diabetes