A
Jaundice is not clinically visible until bilirubin exceeds this plasma level
2.0 mg/dL
What protein carries unconjugated bilirubin in blood?
Albumin
Which enzyme in the liver conjugates bilirubin?
UDP-glucoronyl transferase
Similar to Dubin-Johnson but without pigmentation
Rotor Syndrome
Which type is present in urine?
Conjugated bilirubin
In polycythemia, which type of bilirubin predominates?
Unconjugated Bilirubin
Which enzyme converts heme to biliverdin?
Heme oxygenase
Which form is neurotoxic and can cause kernicterus?
Unconjugated bilirubin
Product produced from intestinal bacterial action on B2
Urobilinogen
Cause severe neonatal jaundice with kernicterus due to complete absence of UDPGT
Crigler-Najjar Syndrome Type I
Cofactor needed by ALA synthase for heme synthesis
Vitamin B6 (Pyridoxal phosphate)
Type of bilirubinemia associated with fat malabsorption
Conjugated hyperbilirubinemia
Which liver disease can cause mixed conjugated and unconjugated hyperbilirubinemia?
Hepatitis or Cirrhosis
What transporter is defective leading to impaired excretion of conjugated bilirubin in Dubin-Johnson syndrome?
MRP2 (multidrug resistance protein 2)
Management for physiologic jaundice of the newborn to prevent kernicterus if the bilirubin level is already dangerously high
Exchange transfusion