Would ketamine treatment help if you didn't know you got it?
Ket works by binding to this specific receptor in the brain?
NMDA Receptor
What were the long term effects Christopher experienced?
Participants in this study recieved a low dose of ketamine that wore off within an hour or so. What was the result?
More than 70% got better.
What was the difference between participants who recieved ketamine and those who didn't?
Statistically no difference.
Describe dissociation
A state where you no longer feel connected to your own body or even your own thoughts and feelings.
how was ketamine administered?
intravenous injection
Is ketamine a psychedelic?
Not a classical psychedelic but has psychedelic properties
Ketamine is a schedule 1 drug. T or F
False
What were the two aims of the study?
1. if ketamine has rapid antidepressant effects
2. if a single dose of ketamine is sustained
T or F... anesthesia boosts mood.
False
Explain psilocybin-assisted therapy.
They have a blindfold on. They have headphones on, listening to music. Encourage them to go inward and to experience whatever is going to come up with the psilocybin. At the end of the day, we have time for reflection and to talk about what their experiences were before sending them home with a support person.
Briefly describe Boris' 2023 study design.
40 patients, schedules to have some basic surgery and go under anesthetic, history of major depression.....
Is there a relationship between dissociation and anti-depressive effects?
Yes
describe the findings in figure 3 of the study (a+b)
greater proportion with 50% change in score from baseline in ketamine group vs placebo group for all times, day 1 is strongest but it is sustained
only ketamine group was in remission even during 7 days