CV /HTN TRIALS
In the FINEARTS study, pts with HF and mildly reduced or preserved EF on this drug resulted in a significantly lower rate of composite of total worsening of HF events and death from CV causes
What is Finerenone?
nonsteroidal MRA so less effect on K and creat
3 yr f/u
only 13% on sglt2
In the SURMOUNT-OSA trial, among pts with mod-severe obesity this drug reduced the apnea-hypopnea index, systolic bp and improved sleep related outcomes
What is Tirzepatide?
Similar outcomes with or without CPAP use
The Wisdom trial compared risk based vs annual breast cancer screening showed non inferiority in the rate of detecting breast cancer, but did not reduce this rate
What is rate of biopsy?
Selection bias as pts chose which arm so not randomized and underpowered as number of cancers detected was low
In the Vesalius trial Evolocumab (Repatha) led to a lower risk of this event in pts with DM or atherosclerosis but without prior mi or stroke
What is cardiovascular event? MACE 3 and 4
First major trial as primary prevention in high risk pts
Most on high dose statin
Predominantly white pop 4.5 yrs
In this prospective cohort trial in MSM the HIV incidence did not differ between the use of which 2 regimens?
What is daily PrEP vs on demand pre-prophylaxis?
Study in France Alot of selection bias an confounding (pts chose which arm in trial) with high drop out and low rate of outcome
in the OCEAN trial pts who had successful catheter ablation of atrial fibrillation, this drug did not lower incidence of stroke/embolism/covert embolic stroke as compared to asa.
What is rivaroxaban?
open label, underpowered with very few strokes due to selection bias with low chadsvasc scores, sample size too small
Used MRI to look for covert embolic strokes
In a single center trial this medication was associated with a reduced risk of SARS-COV-2 respiratory infection.
What is azelastine nasal spray?
Single center in Germany
only 56 days and unclear blinding given taste assoc with the med
In the trial BPROAD, in pts with T2DM the incidence of what condition was significantly lowered with treatment of BP to less than 120 instead of 140 systolic?
What is incidence of major cardiovascular events?
Study in China, not blinded, Intervention did achieve clear difference in BP 121 vs 133
Only 60% on a statin and 4% on GLP1