DESTINY Breast-04
This trial evaluated Enhertu in HER2-low metastatic breast cancer and included only 58 patients with metastatic triple-negative breast cancer (mTNBC).
What is DESTINY-Breast04?
Charles claims this is the most important part of any sales call: “Bring donuts, and they’ll remember the drug name later.”
What is breakfast bribery?
ASCENT-03 combined sacituzumab govitecan with this immune checkpoint inhibitor in PD-L1 positive TNBC.
What is pembrolizumab?
This state celebrates Mardi Gras so hard that it has an official law allowing you to ride a horse in a parade while wearing a mask.
What is Louisiana?
Out of 167 total trial sites for Tropion-Breast01, approximately what percentage were located in the United States?
What is about 8%?
Despite being studied in DESTINY-Breast04, Enhertu received this NCCN category designation for mTNBC.
What is Category 2A?
Charles insists this is the best way to explain mechanism of action: “Draw it on a napkin during lunch.”
What is napkin pharmacology?
This study shows a detrimental breakdown in the OS for U.S, Canadian, and European patients vs other geographic regions of the world
TROPION-Breast02 trial
This state is home to a city that claims to have the world’s largest artificial Christmas tree made entirely of aluminum.
What is Tennessee? (Fun fact: Knoxville once had this quirky holiday claim!)
Patients in Tropion-01 had a median of this many prior systemic therapy lines, compared to seven in TROPiCS-02.
What is three?
DESTINY-Breast04 was not powered for statistical significance in this subgroup of patients.
What is mTNBC?
Charles says this is the secret to handling objections: “Agree, then pivot to the free samples.”
What is the sample shuffle?
This study used American Standard of Care treatments of Taxanes and Gem/Carbo
TROPION-02
This state is the only place in the U.S. where you can legally dig for diamonds and keep what you find.
What is Arkansas? (Crater of Diamonds State Park!)
In Tropion-01, this percentage of patients were Asian, compared to only 3% in TROPiCS-02.
What is 41%?
Approximately 80% of NCCN panelists did not find Enhertu’s mTNBC data compelling enough to grant this designation.
What is Category 1?
Charles believes this is the ultimate closing technique: “Mention the rebate program at least five times before dessert.”
What is the sweet deal closer?
In TROPION-02, datopotamab deruxtecan demonstrated this improvement in median progression-free survival compared to chemotherapy.
What is 10.8 months versus 5.6 months?
This state is so flat that a popular joke says it’s “flatter than a pancake,” and a scientific study actually confirmed it.
What is Kansas?
In Tropion-01, 37% of patients had two prior lines of therapy, while this percentage had only one lines.
What is 63%?
DESTINY-Breast04 primarily focused on this HER2 status, which differs from Trodelvy’s mTNBC indication.
What is HER2-low?
Charles proudly states this is his motto: “If you can’t pronounce the drug name, just say ‘the one with fewer side effects.’”
What is the confidence-over-accuracy approach?
Tropion Breast 02 had a median follow-up of 27.5 months with a median OS significantly longer at this rate
23.7 months with datopotamab deruxtecan compared with 18.7 months with chemotherapy
This state is home to a town named Tightwad, which got its name from a dispute over a 50-cent watermelon.
What is Missouri?
What was the NCCN recommendation status for Datopotamab deruxtecan based on Tropion-01?
What is “Other Recommended Regimen”?