They are the circles deleted from T cells after TCR gene rearrangement.
What are TRECs?
100
This delivers signals from the pre-BCR that mediates survival, proliferation, and maturation beyond pre-B cell stage
What is Btk?
100
Besides swans, this is another bird connected with Boston.
What is ducks?
100
Any substance that nonspecifically causes B cells to proliferate.
What is a B cell mitogen?
100
A thickening of the airway walls due to hyperplasia and hypertrophy of the smooth muscle layer and mucus glands, with the eventual development of fibrosis, that occurs in chronic asthma.
What is airway tissue remodeling?
200
In Ig heavy chain rearrangement, they are the first two regions to rearrange.
What are D and J?
200
A mutation in this gene results in autoimmune polyendocrine syndrome.
What is AIRE?
200
This is why Boston is known as beantown.
What is because molasses was plentiful from Boston's trade routes?
200
Cell-surface proteins on bacteria that enable them to bind to the surfaces of host cells.
What is adhesins?
200
A local skin reaction that can be induced to show the presence of IgG antibodies against a particular allergen. Antigen injected into the dermis reacts with IgG antibodies in the extracellular spaces, activating complement and phagocytic cells to produce a local inflammatory response
What is an arthus reaction?
300
This complex of proteins cleaves DNA between a hepatomer and a coding segment.?(hint: Omenn’s)
What is RAG1/RAG2?
300
Mutations in this gene can lead to selective IgA deficiency or CVID
What is TACI?
300
This is the year the Boston marathon started.
What is 1897?
300
Large, rapidly dividing activated B cells present in the dark zone of germinal centers in follicles of peripheral lymphoid organs.
What is centroblasts?
300
A low-affinity Fc receptor for IgE.
What is CD23?
400
This endonuclease opens up the DNA hairpins at the coding ends during rearrangement.?(hint: Omenn’s)
What is Artemis?
400
These 2 TNF family cytokines are essential for B cell survival and activation.?(1 of 2 for points)
What are BAFF and APRIL?
400
This person led the Boston Tea Party.
What is Samuel Adams?
400
Neonatal Fc receptor, a receptor that transports IgG from mother to fetus across the placenta, and across other epithelia such as the epithelium of the gut.
What is FcRn?
400
CC chemokines that act predominantly on eosinophils.
What is eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26)?
500
The mechanism of junctional diversity where N nucleotides are randomly added is mediated by this enzyme.
What is TdT?
500
Mutations in any of these 5 things can lead to Hyper-IgM syndrome.?(All 5 for points)
What are CD40L, CD40, NEMO, AID, and UNG?
500
This is when the Big Dig officially got funding and began.
What is 1987?
500
The rule that for a helper T cell to be able to activate a B cell, the epitopes recognized by the B cell and the helper T cell have to be derived from the same antigen (that is, they must originally have been physically linked).
What is linked recognition?
500
Skin protein, defects in which have been linked to an increased risk of developing atopic eczema.