Ouch! Cell Injury
Developing Development
I'm a Cancer. What's your sign?
A Test of Tests
GRAB BAG
100
Karyolysis, karyorrhexis, pyknotic nuclei and hypereosinophila are all examples of this type of cell injury.
What is irreversible cell damage?
100
This developmental disorder often includes gene deletions of TACI and ICOS.
What is CVID?
100
These proteins are responsible for dysregulation of the cervical cell cycle in HPV viruses 16 and 18.
What are proteins E6 (p53) and E7 (Rb)?
100
Name this disorder - it's a barium study (slide 8).
What is colorectal cancer?
100
This is the most common gene mutation that leads to colon cancer.
What is APC?
200
These ligands, expressed on both WBC's and endothelial cells, are responsible for extravasation of WBC's across post-capillary venules.
What are PCAM and VCAM?
200
Name this defect and one developmental syndrome associated with it (Slide 4).
What is a coloboma, associated with DiGeorge syndrome?
200
This chemotherapeutic treatment is used in treating cancers like Hodgkin's lymphoma by inducing DNA strand breaks.
What is Bleomycin?
200
A 12 year old presents to your clinic with R. leg pain and weight loss. Based on the x-ray, what is your diagnosis? (Slide 9)
What is Ewing's sarcoma?
200
These are the most common three routes via which a cancer may metastasize.
1. Peritoneal seeding 2. Hematogenous 3. Lymphatic spread
300
See Slide 1 and name the major/minor criteria for this disease.
Acute Rheumatic Fever - Jones criteria: Joint pain, pancarditis, erythema marginatum, subcutaneous nodules, Syndham's Chorea. Minor: Fever, arthralgia, elevated acute-phase proteins, PR
300
A classical example of epigenetics, this disorder results from a paternal deletion on chromosome 15. The presentation includes: infantile hypotonia with FTT, short stature, childhood obesity, hypogonadotropic hypogonadism and hypothalamic abnormalities.
What is Prader-Willi syndrome?
300
Osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas and sebaceous cysts are all traits that distinguish this autosomal dominant cancer trait from familial adenomatous polyposis.
What is Gardner's syndrome?
300
These are the three serum tests that point you towards a Down Syndrome diagnosis.
What causes a decreased MSAFP, an increased Inhibin A and decreased estriol values?
300
These are the three organs most likely to be affected by a white infarct.
What are the kidney, spleen and brain?
400
These are the one criteria and the five classic symptoms of Kawasaki's disease, as well as the affected population.
What disease do the following describe? Criteria: 5+ day history of fever Symptoms: Involvement of extremities, mucocutaneous desquamation, polymorphous rash, unilateral cervical lymphadenopathy, bilateral conjunctival injections
400
Gilbert's disease, a congenital abnormality, results in jaundice by this mechanism.
What is a lowered UDPGT-1 activity level?
400
Describe the most likely cancer syndrome and genetic link (See slide 5). Patient presents with tachycardia, respiratory distress and a pale oral mucosa.
What is Burkitt's Lymphoma with an 8, 14 translocation. Associated with EBV.
400
This is the differential for this immunofluorescence slide you accidentally dropped (Slide 7) while in the path lab. You can tell that it is a stain of the dermal/epidermal layer, but nothing else.
What are Discoid Lupus Erthythematosus, Systemic Lupus Erythematosus and Bullous Pemphigoid.
400
This gene mutation renders some individuals highly resistant to HIV infection.
What is the delta-32 mutation of CCR5?
500
A patient presents with rather systemic symptoms: including lymphadenopathy, easy bruising and an irregular heartbeat. Being the astute pathologist that you are, you order a specific stain for some tissue samples (Slides 2-3). Name the condition and the abnormality behind it.
What is Primary Amyloidosis with beta-pleated sheet protein folding? (Fine, fine. It COULD also be secondary amyloidosis due to multiple myeloma. The point is: it's amyloidosis. And it really is Congo Red dye. I swear.)
500
The criteria for this autosomal dominant condition are as follows: 1. Patient diagnosed with a sarcoma before 45 2. First-degree relative has been diagnosed with any cancer before 45 3. Another relative diagnosed before 45 or with a sarcoma at any age.
What is Li Fraumeni Syndrome?
500
This transcriptional factor plays a key role in angiogenesis, especially for tumor cells.
What is Hypoxia-Inducible Factor 1-Alpha?
500
Describe the abnormality (Slide 6)
What is a posterior MI?
500
This elevated lab level allows you to predict RA in a patient years before they are symptomatic.
What is anti-ccp (anti-cyclic citrullinated peptide)?
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