Mechanism of Action
Which medication:
-provides a partial dopamine agonist at D2 receptors
-partial agonism of 5HT1A
-blockage of 5HT2A
-Blockade of serotonin type 2C and 7 receptors
Aripiprazole
partial D2 antagonism theoretically reduces dopamine output when high to address positive symptoms and increases dopamine output when concentrations are low for negative symptoms.
does have actions at D3
blockade of serotonin 2C and 7 receptors may contribute in addition to 5HT1A
insomnia
headache
exacerbation of tics
irritability
anorexia
weightloss
temporarily slow normal growth in children
Amphetamine
(Ask barnwell if he has read any studies about the kddos)
ADHD
boom mic drop
Atomoxatine
approved for adults and children over 6
Can cause arrythmia, siezure, lethal in overdose, induction of mania, rare activation of SI.
Amoxapine or Amitriptyline
Serves as an "artificial alcohol". It may be less effective in situations in which the individual has not yet abstained from alcohol or suffers a relapse
Acamprosate
...thuse acamprosate may be a preferred treatment if the goal is complete abstinence, but may not be preferred if the goal is reduced-risk drinking
Which medication:
-is a norepinephrine reuptake inhibitor
-likely also increases dopamine in the prefrontal cortex
Atomoxetine
despite its name as a selective norepinephrine reuptake inhibitor, atomoxetine enhances both dopamine and NE in the prefrontal cortex presumably accounting for therapeutic actions on attention and concentration.
blurred vision
constipation
urinary retention
Dizziness
Fatigue
Sexual Dysfunction
Amitriptyline
ADHD
Narcolepsy
Exogenous obesity
Amphetamine
Unlike stimulants, may not exacerbate tics in tourettes syndrome in patients with comorbid ADHD.
Atomoxetine
What schedule drug is Alprazolam or Amphetamine?
IV
Which medication:
-is a dopamine and norepinephrine reuptake inhibitor AND releaser
Amphetamine
-increases norepinephrine and especially dopamine actions by blocking their reuptake and facilitating release
-action at the dorsal lateral prefrontal cortex may improve attention, concentration, executive function, and wakefulness
sedation
fatigue
depression
dizziness
ataxia
slurred speech
weakness
forgetfulness
confusion
Alprazolam
-reducing excessive sleepiness in patients, with narcolepsy and sleep shift disorder
-reducing excessive sleepiness in patients with OSA/hypopnea syndrome
Armodafinil
Off label indications:
ADHD, bipolar depression, fatigue and sleepiness in depression, fatigue in MS
If taken with food, may delay action of onset by 2-3 hours. So it's recommend to take on an empty stomach
LAI that requires 14 day overlap of oral medication
Abilify Maintenna
Which medication:
-blocks serotonin reuptake
-blocks norepinephrine reuptake
-desensitizes both serotonin 1A receptors and beta adrenergic receptors
-increases dopamine concentrations in the prefrontal cortex via inhibition of norepinephrine reuptake in the prefrontal cortex.
Amitriptyline
-theoretically effective by increasing amounts of serotonin, norepinephrine, and dopamine levels within the prefrontal cortes.
anxiety, depression, and SI
nausea
Diarrhea
Acamprosate
schizophrenia, acute and maintenance (adults)
acute mania/mixed mania, monotherapy (ages 10-17 and adults)
acute mania/mixed mania, adjunct to lithium or valproate in adults
Asenapine
Generally has a longer Biological duration of action than clonazepam
Alprazolam XR
LAI that requires 21 day overlap of oral medication
Aristada
unless you give an initio injection, then just give one 30mg tablet of abilify in addition to aristada
Which medication:
-"glutamate multi-modal"
-theoretically reduces excitatory glutamate neurotransmission and increases GABA transmission
Acamprosate
-exact mechanism unknown. binds to and blocks certain glutamate receptors reducing transmission
sedation
dizziness
oral hypoesthesia
akathesia
Tardive dyskinesia
Application site reactions: oral ulcers/blisters, peeling/sloughing
Asenapine
Depression
Amitriptyline
off label uses:
anxiety, OCD, neuropathic pain, insomnia, prevention of migraine
Time to reach steady state is 4-5monthy injections
Ablify maintenna or Aristada
Analgesic that has the potential to induce serotonin syndrome if given with serotonergic agents.
Tramadol
Tramadol inhibits the reuptake of the natural neurotransmitters norepinephrine (noradrenaline) and serotonin, and also binds weakly to μ-opioid receptors, blocking the transmission of pain signals to the brain.