Autoimmune (3)
Lymphocytic infiltration around glandular ducts of exocrine cells
Sjogrens
Inflammation of the ear, sparing the lobule
Relapsing Polychondritis
GPA
C-ANCA
Nikolsky Sign
dislodgement of intact superficial epidermis by a shearing force (PV)
Infectious Bacterial (3)
Cat scratch (Bartonella Henselae), rhinoscleroma (Klebsiella), TB, non-TB mycobacterium, leprosy, syphilis (treponema pallidum), actinomycosis
Small to medium sized vasculitis, Necrosis, Poorly formed granulomas, Micro-abscesses and parenchymal inflammation
GPA
Sjogrens
EGPA
P-ANCA
Bamboo Nodes
Submucosal lesions at mid vocal folds (SLE, RA)
Infectious Fungal (x3)
Langerhans giant cells which contain cytoplasmic inclusions such as laminated mucopolysaccharide Schaumann bodies and collagen asteroid bodies
Sarcoidosis
Eosinophilic Granulomatosis with Polyangitis
Sjogrens - two hallmark antibodies
Anti-Ro, Anti-La
Heerfordt’s syndrome
Uveoparotid fever (facial nerve palsy, parotid gland enlargement, anterior uveitis, and low grade fever) - Sarcoidosis
Trauma (x1)
Intubation, teflor granuloma
Apple green birefringence with Congo Red staining in polarized light
Amyloidosis
Enlargement of organs, proteinuria, stridor
Amyloidosis
This test may be used to help diagnose sarcoidosis
ACE levels
Rose-Bengal Score
Dye instilled in the eyes to assess damage to eyes (score eye dryness) - Sjogrens
Neoplastic (x1)
Histiocytosis (langerhans cell granulmoatous), pyogenic granuloma, T-cell lymphoma
Acantholysis with intercellular clefts progressing to suprabasilar blister formation; resembles row of 'tombstones'
Pemphigus Vulgaris
Apthous ulcers, recurrent painful genital ulcers, uveitis/conjunctivitis
Behcet's Syndrome
Relapsing Polychondritis has antibodies against this
Type II collagen
Lofgren Syndrome
Acute specific presentation of sarcoidosis (erythema nodosum, hilar adenopathy, polyarthralgias)