Lung Pourri
I am the recommended scan for individuals aged 50-80 and in good health, quit smoking in the last 15-years, and had at least a 20-pack year smoking history
What is an annual low-dose CT scan
This trial has a similar trial design as EVOKE-02
What is TROPION-Lung-02
Pembrolizumab + pemetrexed + carboplatin regimen in non-squamous
What is KEYNOTE-189
This VEGFR-2 targeting agent was added to docetaxol in the REVEL study and showed a statistically significant OS benefit (~ 2months) over docetaxol alone.
what is ramucirumab or Cyramza
Lived in Gothenburg, Sweden
Who is Xiaocui
Star Trek super fan
Who is Tim Farley
1000x more potent
What is SN-38 versus irinotecan). **DAILY DOUBLE**
This trial included Dato DXd + durvalumab + chemo
What is TROPION-Lung-04
Pembrolizumab + nab-paclitaxel + carboplatin regimen in squamous cell carcinoma
What is KEYNOTE-407
This is the recommended dosing of docetaxol when used in NSCLC and is also the dose of docetaxol that was used in the control arm of EVOKE-01.
What is 75mg/m2
This colleague has a BFF currently working on the USMA Trodelvy Breast team
Who is Morgan Miller
This colleague is the Queen of Halloween
Who is Jill Piazza
This study is in the 1L and includes dom + zim + chemo versus pembro + chemo
What is STAR-121
ORR 57% and DCR 91%
What are efficacy data for TROPION-Lung-02's Dato DXd + pembro cohort
Also known as EVOKE-03
What is KEYNOTE-D46
Docetaxol is one of the taxane family of chemotherapies and binds to this cellular structure thereby preventing cellular division and promoting apoptosis.
what are microtubules
This person has a fur baby named after a key character in Game of Thrones
Who is Jamal Sims
Who is a Chess Camp Master
Who is Mark Fooladi
I am a small molecule CD73-inhibitor
What is quemliclustat
In TROPION-Lung-02 ASCO 2023 data, this cohort had the highest discontinuation rate between the two
What is the doublet cohort - 64% versus 54%
ORR was 44.8% in the pembrolizumab group and 27.8% in the chemotherapy group
What is KEYNOTE-024
The docetaxol package insert has a black box warning with 5 listed toxicities. Name two of the five
What are toxic death, hepatotoxicity, neutropenia, hypersensitivity reactions and fluid retention
According to the ‘Blue Zones’ this person will live the longest
Who is Segundo Gallo
This teammate hosts a family games night every 2 weeks on zoom
Who is Judy Brennan
I am expressed on immune cells and mediate the immunosuppressive effects of adenosine
What are A2a and A2b receptors
This trial reported All Grade ILD rate of 22%
What is TROPION-Lung-02's Dato DXd + pembro + chemo cohort
Published in New England Journal of Medicine in 2016 with Martin Reck as lead author led to single-agent pembrolizumab as SOC for >50% PD-L1 expression
What is KEYNOTE-024
This is the name of the recent failed Phase III study comparing docetaxel to pembrolizumab plus lenvatinib in the 2nd line NSCLC setting
What is LEAP-08
2 team members are mothers to teen/tween-age children and fur babies, as well as keen campers
Who is Arti and Cathy
2 team members have worked together at 3 companies
Who is Kin Lam and Kevin Peterson