Basic Concepts
The ability of bacteria to survive and grow despite antibiotic treatment
What is antimicrobial resistance (AMR)?
Type of bacteria that served as baseline group (comparison group)
What is wild-type (WT)?
Bacteria lacking Mfd protein showed this resistance development
What is reduced resistance?
Process that allows bacteria to gain resistance
What is evolution?
Symbol that indicates protein (ex. Mfd) was removed
What is ∆?
Bacteria regained its ability to mutate
What is adding Mfd protein back?
Mfd Protein
What is an evolvability factor?
Antibiotic used to treat Tuberculosis
What is Rifampicin?
Mtb
What is mycobacterium tuberculosis?
Aims to stop bacteria from evolving
What is inhibiting evolution?
Process to grow bacteria to observe changes in resistance
What is evolution experiment?
Mfd helps bacteria do this faster
What is mutate?
Random DNA changes that are the main source of antibiotic resistance
What are mutations?
RNA polymerase subunit
What is RpoB?
Overall goal of research article
What is inhibiting antibiotic resistance?