Germ Layers
Three Kidneys
Molecular Signals
Surprise 👀
100

These two embryologic tissues contribute to the formation of the adrenal glands.

What are intermediate mesoderm and neural crest cells?

100

This is the permanent kidney that forms during development.

What is the metanephros?

100

This gene is necessary for nephron development and knockout mice lack nephrons.

What is PAX2?

100

During development, kidneys begin in this region of the body and end up in this other region by 9 weeks of development.

What are the A) pelvic region and B) upper lumbar region?

200

This germ layer gives rise to the kidneys and ureters.

What is intermediate mesoderm?

200

This first nephrogenic system forms in the cervical region and quickly degenerates.

What is the pronephros?

200

This gene is required for collecting system development.

What is LIM1?

200

This embryologic kidney system contributes to the male reproductive tract through the Wolffian duct but persists in females only as vestigial structures such as the Gartner duct.

What is the mesonephros?

In males, the mesonephros (mesonephric/Wolffian system) contributes to the epididymis, ductus deferens, and seminal vesicles, while in females it largely regresses but leaves small remnants such as the epoophoron, paroophoron, and Gartner duct.

300

These two tissues form from intermediate mesoderm and give rise to major urinary system structures.

What are the nephric cord and nephric duct?

300

This temporary kidney produces urine for about four weeks and later contributes structures to the male reproductive system.

What is the mesonephros?

300

These two signaling molecules secreted by the mesenchyme stimulate ureteric bud formation.

What are GDNF and HGF?

300

These are the weeks during which the pronephros, mesonephros, and metanephros develop.

Pronephros: week 4 (appears early week 4 and quickly degenerates)

Mesonephros: weeks 4–8

Metanephros: begins week 5 and functions by ~week 9

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