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When tissue is injured, the body's initial local reaction is to release a variety of chemical mediators, including histamine, heparin, leukotrienes, prostaglandins, & cytokines. Generally speaking, what do these mediators do and why is it important in the inflammation process?
Histamine - increases cap permeability
Heparin - anti-coagulant
Leukotrienes - released by damaged cell, attract WBCs
Prostaglandins - released by damaged cell, vasodilate and stimulate free nerve endings
Cytokines - vasodilators