Basics of Hemostasis and Immunology
These are the 3 main pathways of the coagulation cascade
What are the intrinsic, extrinsic, and common pathways
This is the preferred anticoagulant for most coagulation assays
What is sodium citrate
This is the most common inherited coagulation disorder of domestic animals
What is von Willebrand disease
DEA stands for this
Dog erythrocyte antigen
This is a consumptive disorder characterized by the depletion of platelets and coagulation factors
What is Disseminated Intravascular Coagulation
This cell's name changes depending on where it is in the body
What is a monocyte
The most common type of immunologic test to run in practice
What is the Enzyme linked immuno-sorbent assay (ELISA)
Atopy and anaphylaxis are this type of hypersensitivity reaction.
(Hint: IgE mediated)
What is type 1
This is the most common blood type among cats in the United States
What is type A
The normal number of platelets per 100x oil immersion field
What is 8-10
This factor helps stabilize platelet plugs
What is von Willebrand's factor
This test is a primary assay in the detection of abnormalities in platelet function or number.
(Hint: the patient should be anesthetized for this test)
What is the buccal mucosal bleeding time (BMBT) test
This is the primary site of production of coagulation factors.
This blood type is the most clinically significant among dogs because it causes the most severe transfusion reactions
What is DEA 1
The ACT test uses a tube containing one of these two materials
What are dietomaceous earth and kaolin
Name the 5 classic signs of inflammation
What are redness, heat, pain, swelling, and loss of function
A test that yields a result that is truly negative has a high...
What is specificity
Type 4 hypersensitivity reactions are mediated by these cells.
What are T-lymphocytes
A major crossmatch involves the mixing of these components
What is donor RBCs and recipient plasma
This test can evaluate every clinically significant clotting factor except for Factor VII.
(Hint: this is NOT usually part of a standard coagulation panel)
What is the activated clotting time (ACT)
When platelets are activated, this is expressed on their surface and acts as a binding site for the complexes of the coagulation cascade
What is phosphatidylserine
Antibody titers are test and reported based on this concept.
Hemophilia A is caused by a deficiency of this coagulation factor.
What is factor VIII
Name the two methods used in clinic to perform blood typing
What are immunochromatography and agglutination
Activation of the complement cascade can lead to these 3 things
What are opsonization, inflammation, and cell lysis