Introduction
Who was the first to describe autism and when?
Kanner (1943)
What does comorbidity mean?
What percentage of people have a certain disorder + another one
1000, Biomarkers
What are islets of ability a result of?
Hyperconnectivity
What is the diagnosis window for ASD
6mo. to 3yo.
What percentage of ASD patients experience Sleep disorders?
60%
Give an example of copy number variation and classify it
Normal gene: ABCD
Deletion - ACD
Duplication - ABBCD
Inversion - BACD
Insertion - ABECD
What does weak coherence mean?
People with ASD have a hard time seeing the bigger picture (they hyper fixate on details)
How much more likely is ASD in boys?
4
What percentage of ASD patients experience Fragile X Syndrome?
5%
Where does fragile X syndrome occur?
Chromatin fiber
What do people with ASD have trouble noticing?
Faces
What is an ASD diagnosis based on?
Behaviors
What is considered advanced paternal age? Maternal Age
M = 40+
What is pruning? What is macrocephaly? How are they related?
Pruning - the shaving off of neurons in your brain
Macrocephaly - an enlarged brain
Lack of pruning causes macrocephaly
What is mind blindness?
Why is ASD considered a heterogenous condition?
Wide variety of symptoms
Wide variety of intensity (high functioning/ mild symptoms)
Name all the risk factors for ASD
Genetics
Advanced paternal age
Advanced maternal age
Maternal hypertension
Maternal infections
Premature birth
Low birth weight
List all the brain parts associated with ASD
Amygdala
Basal Ganglia
Hippocampus
Brain Stem
Cerebellum
Corpus Callosum
Cerebral Cortex
Explain the Sally/Anne Task and what it shows
Sally has a basket with a marble in it, Anne has a box
Sally walks away
Anne takes the marble, and throws it in her box
Ask the child "where will Sally look for the marble"
Shows theory of mind