Match that gene
FAP syndrome is a mutation in which gene?
What is APC?
Gardner = FAP + osteoma and dental abnormalities
Turcot - FAP with CNS tumors
These are screening recommendations for Lynch syndrome
Colonoscopies starting 20-25;
EGD with consideration of extended duoendoscopy beginning at age 30-40
TAH/SBO once childbearing complete for endometrial (60% lifetime risk)
Annual urinalysis (bladder or upper uroltheilail)
Breast MRI at 20 years old; consider mastectomy
One should not give traztuzumab below this EF
What is 30%?
Gardner Syndrome and Turcott syndrome are subsets of FAP. What are these also associated with?
Gardner = desmoid
Turcott = brain tumors
This prophylaxis is needed with TMZ?
What is Bactrim?
PTEN mutation is associated with which disorder?
What is Cowden syndrome?
Autosomal Dominant
PTEN
Mucocutaneous lesion, Macrocephaly
High risk benign and malignant tumors of follicular thyroid, endometrium and breast Colorectal, renal cell, autism
These are screening recommendations for BRCA carriers
Breast exam at 25
Mammograms starting at 30
MRI annually at age of 25 - 75
NO transvaginal ultrasound or CA125
Bilateral mastectomy and SOO at age 35-40 (for BRCA2 40-45); maybe also tamoxifen and AI
BRCA2 - consider prostate cancer screening in men
This is the toxic component of ifosfamide that mesna binds to
What is acrolein?
Most genetic disorders in oncology are autosomal dominant. Name one that is autosomal recessive.
What are MUTYH Associated polyposis and Xeroderma Pigmentosum?
T/F Capecitabine cannot be given at Cr Cl < 30
What is true
One might see this on physical exam in a disorder associated with STK11
What is mucocutaneous lesions?
Peutz-Jeghers Syndrome
STK11 gene - autosomal dominant
GI hamartomas - "frond like"
Mucocutaneous pigmentation
Breast Cancer (manage like BRCA ½)
Colorectal, stomach, pancreas, small bowel, Ovarian, testicular, cervix, uterus, Lung
This is when one should start screening for colon cancer in patients with FAP
What is 10 years old?
Consider preventative colectomy
This is the treatment for MTX overdose
What is glucarpidase?
Sotarasib/Adagrasib have these electrolytes disturbances
What are hyponatremia and hypocalcemia?
This is how long one should give entecavir post rituximab after completion of therapy
What is 12 months?
This mutation is associated with Familial Mole syndrome.
What is CDKN2A?
Melanoma/pancreatic tumors
Patient has a syndrome associated with CDH1 mutation - what should be recommended to him prophylactically
What is prophylactic gastrectomy at age 18-40?
Hereditary diffuse Gastric cancer (also associated with lobular breast cancer and cleft lip/palate)
Mammograms at 30 years old
This is the treatment for 5-fU toxicity
What is uridine triacetate?
This gene associated with Birt Hogge Dube and tumors associated with
What is FLCN
Chromophobe + spontaneous pneumothorax
When giving ribociclib and a patient develops neutropenia without fever on first occasion, what should one do with the ribociclib dose?
What is interrupt and then resume at same level (reduce if recurrent neutropenia or fevers)
These mutations are associated with Juvenile Polyposis
What are SMAD4, BMPR1A?
Associated with HHT
These are screening recommendations for Li Fraumeni Syndrome
ANNUAL Brain MRI and whole body MRI
Breast MRI at 20, Mammogram at 30
Routine skin checks
Routine colonoscopies and upper scopes starting at 25 years old or 5 years before most recent family member
germline p53 mutation
breast, sarcoma (osteosarcoma), brain, adrenocortical, leukemia, choroid plexus, childhood cancers, multiple primaries, radiation induced
One should give this during an anthracycline extravasation reaction
What is Dexrazoxane?
Patient is on 4mg IV morphine. What is this equivalent to in PO dilaudid?
What is 3mg PO dilaudid?
SC Morphine: 3 to 1 [3 mg of oral Morphine: 1 mg of SQ Morphine]
IV Morphine: 3 to 1 [3 mg of oral Morphine: 1 mg of IV Morphine]
PO Dilaudid: 4 to 1 [4 mg of oral Morphine: 1 mg of oral Dilaudid]
PO Oxycodone: 1.5-2 to 1 [1.5-2 mg of oral Morphine: 1 mg of Oxycodone]
PO Tramadol: 1 to 10 [1 mg of oral Morphine: 10 mg of Tramadol]
Loncastuximab is an antibody towards THIS
What is CD 19