Immune System
Secrete cytokines after recognition of danger signals
What are Monocytes and Macrophages
Developed a "Cancer Vaccine"
Who is William.b. Coley
The stimulus that triggers TNF-alpha transcription
What are Lipopolysaccharides
TNF-alpha binds to
What are TNFR1 and TNFR2
Pathology characterized by swelling in the joints
What is Rheumatoid Arthritis
Immune system response to harmful stimuli
What is Inflammation
Found that endotoxins are not effective at tumour necrosis outside of the host
Who is Elizabeth A. Carswell
The cell type that contains TNF-alpha mRNA
What are monocytes
Provides a platform to recruit additional proteins involved in the pathway
What is TRADD
Pathology characterized by swelling in the fingers
What is Psoriatic Arthritis
Pleiotropic cytokine
What is TNF-alpha
Coleys injections contained a major component of endotoxin
What are Lipopolysaccharides
The biologically active precursor form of mature TNF-alpha is found
Where is anchored to the cell membrane
Cell is ubiquitinated within the NF-kb pathway
Pathology characterized by swelling in the gut region
What is Crohns Disease
What is NF-kb Pathway
Carries out the hemorrhagic necrosis of tumours
What is TNF-alpha
The enzyme that converts the membrane bound TNF-alpha to soluble TNF- alpha
What is TACE
cell that when bound leads to degradation of ikb
What is IKK
What is Infliximab
What are released in repose to TNF-a transcription
What are Cytokines
year that cDNA of TNF-a was made
What is 1984
The chromosome that encodes for TNF-alpha
What is chromosome 6
The receptor that interacts mainly with membrane anchored TNF-alpha
What is TNFR2
Anti-Inflammatory drug that is injected subcutaneously
What is Adalimumab