Class/Actions/Uses
What is the therapeutic class of losartan?
Drug for hypertension
What is the onset timing for losartan?
6 hours
Hypoglycemia, dizziness, UTI, fatigue, & anemia
Should patients with a prior hypersensitivity to losartan take this drug?
No
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What is the pharmacologic class of losartan?
Angiotensin II receptor blocker
What is the peak timing for losartan?
1-1.5 hours
What are serious side effects of losartan?
Should losartan be taken during pregnancy?
No
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Do not use during pregnancy
What is the main use for losartan?
Treatment of hypertension
What is the duration timing for losartan?
24 hours
Losartan should be given with caution to which type of patients?
Patients with CKD or hepatic impairment
- Lower doses to avoid toxicity
What is the antidote for losartan?
IV infusion of Normal Saline
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Risk of dizziness
What are some other uses of losartan?
- Reduce the risk of stroke in patients w/ hypertension & left ventricular hypertrophy
- Prevention of nephropathy in patients w/ T2D
What is a patient teaching tip regarding the side effect of dizziness & fainting?
Teach patients to get up slowly from sitting or lying positions
What action should be taken if pregnancy is detected?
Discontinue the drug immediately
What are symptoms that display during overdose of losartan?
Dizziness & fainting (due to hypotension)
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Caution in patients with low fluid volume (hypovolemia)
How does losartan act to lower blood pressure?
Produces vasodilation and reduces blood volume by blocking the angiotensin receptor in vascular smooth muscle & the adrenal gland
Why should losartan not be taken if pregnant?
Risk for fetal harm & death
Which patients are at a higher risk for symptomatic hypotension?
Patients with hypovolemia
Why should losartan not be taken concurrently w/ Aliskiren?
* Aliskiren - drug to treat hypertension*
Increases the risk for severe side effects due to similar outcomes being produced
- Losartan & Aliskiren both work to lower blood pressure which can cause severe hypotension if taken concurrently
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Do not use with prior hypersensitivity to drug