Small but Mighty
Like Carcinoid tumors, Small Cell Lung Cancer is a ____ type of lung cancer
Neuroendocrine
Right main bronchus tumor
+ intraparenchymal nodes
2B
The SAKK trail compared what two treatment arms
chemotherapy followed by radiation
versus
chemotherapy alone
The overall benefit of chemotherapy was found to be an increase of ___% in overall survival
5%
When resection a right upper lobe tumor, this structure is found most anterior in the hilum
right upper lobe vein
Name 2 of the possible paraneoplastic syndromes associated with SCLC
Cushing syndrome
SIADH
Lambert-Eaton syndrome
4.5 cm tumor
negative nodes
2A
The SAKK trail, a phase 3 trial, found _____ benefit to radiotherapy.
No benefit
Improved chemotherapy results correlated with improved _____
performance or functional status
A tumor invades the right mainstem bronchus, this surgical approach will best preserve lung function
sleeve resection
Prior to surgery, these imaging studies are required
Brain MRI
PET-CT
Bronchoscopy
9 cm tumor
negative nodes
3A
INT0139 (2009) studied what treatment arms
chemoradiation + surgery
versus
definitive chemoradiaiton
Within the patient population nearly 50% of patients had ____ cancer, while only 40 had ____ cancer
squamous cell (50%)
NSCLC (40%)
You perform a right upper lobectomy, and the arterial vascular margin is positive at the truncus-right main PA bifurcation. What possible surgical approaches could be done to get an R0 resection
right main PA plasty
or
pneumonectomy
This type of chemotherapy is recommended for SCLC
platinum-based chemotherapy
4 cm right peripheral tumor invading chest wall
+ intraparenchymal nodes, + 4R
3B
INT0139 found a significant difference in _____ survival but not in _____ survival for the surgery group
+ progression free survival (p=0.017)
no benefit to overall survival (p=0.24)
This stage of lung cancer saw no benefit to post-operative chemotherapy, in fact, the subgroup ____ showed the control was significantly better
stage 1
and
1A
The most devastating acute complication of a pneumonectomy is ____
cardiac herniation
Resection of SCLC can occur if the tumor is less than ___ cm and if there are ____ positive nodes.
3 cm and zero nodes
6 cm left lower lobe tumor
+ cervical node
3C
Regarding the type of surgical resection, these patients had the best survival post-operation
lobectomy ~ 35-40% at 5 years
pneumonectomy ~ 25% at 5 years
-------
lobectomy > non-surgica treatment
pneumonectomy = chemorads
When coupled with cisplatin, this chemotherapy agent demonstrated the best results
vinorelbine
There are always more level
7s