consider this...
fever + elevated CRP
infection
generalized arthralgias, myalgias, and fatigue but no photosensitive rash, arthritis, or multisystem organ involvement
Fibromyalgia
backbone of SLE treatment
plaquenil
First line induction therapy for Class 5 lupus nephritis
prednisone + MMF
Antibody associated with drug-induce SLE
Anti-histone
diarrhea + low albumin. bland UA
Hip pain in an SLE patient
osteonecrosis
two medications approved for SLE
Plaquenil and benlysta
first line induction therapy for Class 3/4 lupus nephritis
prednisone + MMF/CYC
Most common drugs causing drug-induced SLE
hydralazine and procainamide
fever + cytopenia + low ESR
MAS
agranulocytosis in a patient previously treated for lupus nephritis
drug-induced
NSAID that may cause rash in SLE
celecoxib (sulfa based)
second line induction therapy for class 3/4 lupus nephritis
rituximab or calcineurin inhibitor
Percent of SLE patients that can have anti-histone antibodies (within 10%)
60%
fever, altered mental status, worsening renal function, hemolytic anemia, and thrombocytopenia
TTP
lymphadenopathy, fever, myalgias, arthralgias. lymph node biopsy with histiocytic cellular infiltrate
Kikuchi
potential tx for severe mouth ulcers in SLE
thalidomide
Maintenance therapy for Lupus Nephritis
most common causes of drug induced SCLE (name 2 of 4 most common)
terbinafine > anti-TNF > anti-epileptics > PPI
SLE in a patient > 50yo
DILE
fever, lymphadenopathy, cutaneous eruptions, and arthralgias but ANA negative
TTP treatment in SLE
PLEX followed by FFP (plasmapheresis to remove the autoantibodies and multimers of von Willebrand factor, followed by fresh frozen plasma to replace the metalloproteinase)
Euro-lupus protocol dosing
500mg IV every 2 weeks x 6 doses
Antibody associated with drug-induced SCLE
Anti-Ro (80%)