Infectious Mononucleosis
This is the primary etiologic agent of infectious mononucleosis
What is Epstein-Barr Virus (EBV)?
This classic cytogenetic translocation found in most cases of follicular lymphoma positions the BCL2 gene next to the immunoglobulin heavy chain gene locus.
What is t(14:18)?
T-cell lymphoblastic leukemia/lymphoma presenting with a rapidly growing anterior mediastinal mass most commonly affects this demographic age group.
What is children & young adults?
The "R" in the standard front-line treatment regimen R-CHOP stands for this monoclonal antibody targeting CD20.
What is Rituximab?
This specific histologic subtype accounts for about 70% of all HL cases and features fibrocollagenous bands dividing the lymph node into nodules
What is Nodular Sclerosis Classical Hodgkin Lymphoma?
EBV primarily targets and binds to this specific receptor (aka: complement receptor 2) predominantly expressed on mature B lymphocytes.
What is CD21?
Rather than the dark and light zones of normal germinal centers, the uniform follicles of this disease notably lack these debris-clearing phagocytes.
What are tingible body macrophages?
At initial presentation, an extremely high count of these blood elements (exceeding 100,000 per microliter) traditionally indicates a higher risk and poorer prognosis in ALL.
What are WBCs?
This specific transcriptional regulator is required for normal germinal center formation and is frequently over-expressed or mutated in DLBCL.
What is BCL6?
These diagnostic malignant cells found in Nodular Sclerosis Hodgkin Lymphoma feature abundant cytoplasm that shrinks during tissue fixation, leaving an empty space around the nucleus.
What is lacunar cell?
This rapid point-of-care test for infectious mononucleosis detects heterophile antibodies that react with horse or sheep RBCs
What is monospot test?
When follicular lymphoma cells spill over into the peripheral blood, they are frequently referred to by this descriptive anatomical nickname due to their cleaved nuclear appearance.
This intracellular enzyme marker is present in most blasts of lymphoid origin.
What is terminal deoxynucleotidyl transferase (TdT)?
This morphological variant accounts for about 85% of all DLBCL cases, featuring nuclei with vesicular chromatin and small nucleoli.
What is centroblastic variant?
Classical Reed-Sternberg cells are universally positive for this specific cell-surface immunohistochemical marker.
What is CD30?
Prescribing this antibiotic to a patient with unrecognized infectious mononucleosis frequently results in a characteristic febrile rash resembling rubella.
What is Amoxicillin?
While reactive follicles are negative for BCL2 in their germinal centers, neoplastic follicles in follicular lymphoma show strong positivity for BCL2 because it functions as an inhibitor of this cellular process.
What is apoptosis?
To classify ALL as T-cell lineage rather than B-cell lineage, flow cytometry must demonstrate positivity for these specific cluster of differentiation markers.
What is CD2, CD5, & CD7?
*Other sources say CD3 as well but Dr. Fender said thats only on mature T cells...
Primary CNS lymphoma and DLBCL in elderly or immunocompromised patients are frequently driven by reactivation of this herpesvirus.
What is EBV?
What is the Ann Arbor staging system?
This rare, fatal X-linked lymphoproliferative disease caused by a mutation in the SH2D1A gene leads to an ineffective immune response specifically to EBV infection.
What is Duncan disease?
Histologic grading of follicular lymphoma is determined entirely by counting the number of these specific large, round-to-oval cells per high-power field.
What is centroblasts?
Up to 70% of all T-ALL cases harbor gain-of-function mutations in this specific gene that is essential for normal T-cell development.
What is NOTCH1?
The sudden, aggressive progression of CLL into high-grade DLBCL is known by this name.
What is Richter transformation?
Following its typical predictable anatomical pathway, Hodgkin Lymphoma most commonly originates in lymph nodes located in this upper region of the body before extending downward.