PHARMACOLOGY
WHAT IS THE DRUG TO TREAT MALIGNANT HYPERTHERMIA CALLED AND HOW MANY MG ARE IN EACH VIAL?
DANTROLENE IN 20MG VIALS OR
RYANODEX IN 250MG VIALS
WHAT OTHER DISORDER HAS MALIGNANT HYPERTHERMIA BEEN LINKED TO?
MUSCULAR DYSTROPHY
WILL THE PATIENT IN MALIGNANT HYPERTHERMIA PRESENT WITH MUSCLE WEAKNESS OR MUSCLE RIGIDITY?
MUSCLE RIGIDITY
WHAT IS THE FIRST THING YOU SHOULD DO WHEN MALIGNANT HYPERTHERMIA IS SUSPECTED?
STOP THE TRIGGERING AGENT
MALIGNANT HYPERTHERMIA IS ALSO FOUND IN WHAT TWO ANIMALS?
PIGS AND HORSES
WHAT DO YOU DILUTE A VIAL OF DANTROLENE WITH AND WITH HOW MANY ML'S?
PRESERVATIVE FREE STERILE WATER FOR INJECTION, 60ML'S PER VIAL
WHAT TRIGGERS MALIGNANT HYPERTHERMIA IN PATIENTS? WHICH DRUG SPECIFICALLY?
GENERAL ANESTHESIA /SUCCINYLCHOLINE
THE PATIENT IN A MALIGNANT HYPERTHERMIA CRISIS STARTS TO SHOW VERY DARK URINE. WHAT IS THIS CALLED?
RHABDOMYOLYSIS
WHAT SHOULD YOU DO WITH THE PATIENT'S OXYGEN WHEN MALIGNANT HYPERTHERMIA IS SUSPECTED?
HYPERVENTILATE WITH 100% O2
NAME TWO COMPLICATIONS THAT ARISE FROM MALIGNANT HYPERTHERMIA.
WHAT IS THE CORRECT WEIGHT BASED STARTING DOSE FOR DANTROLENE?
2.5 MG PER KG
MALIGNANT HYPERTHERMIA CAN BE CAUSED BY THE EXTERNAL ENVIRONMENT? (T/F)
TRUE
WHAT IS THE FIRST SIGN OFTEN SEEN IN MALIGNANT HYPERTHERMIA?
RISING END TIDAL CO2
HOW MANY TOTAL VIALS OF DANTROLENE SHOULD ALWAYS BE IN THE M.H. CART?
36 VIALS
ONE IN HOW MANY PATIENTS HARBOR THE GENETIC CHANGE THAT MAKES THEM SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA?
1 IN 2,000 PEOPLE
RYANODEX CCOMES IN 250MG VIALS TO BE MIXED WITH.
WHAT IS 5ML OF STERILE WATER.
THE BUILDUP OF WHAT MINERAL CAUSES MUSCULAR RIGIDITY IN MALIGNANT HYPERTHERMIA?
CALCIUM
HOW HIGH HAS THE TEMPERATURE BEEN SEEN TO GET IN MALIGNANT HYPERTHERMIA?
UP TO 110 DEGREES
YOU STABILIZE YOUR PATIENT IN MALIGNANT HYPERTHERMIA, WHAT IS THE NEXT STEP?
WHAT IS SEND/ADMIT TO ICU FOR 24-48 HOURS.
WHAT IS THE NORMAL RANGE OF ETCO2?
35-45 mmHG
YOUR PATIENT WEIGHS 50KG. HOW MANY VIALS OF DANTROLENE WOULD YOU NEED FOR THIS PATIENT?
(THIS IS A MULTI-STEP MATH PROBLEM)
50 KG X 2.5MG = 125 MG DOSE
20MG PER 1 VIAL OF DANTROLENE
ANSWER= 7 VIALS OF DANTROLENE NEEDED
WHAT CLOTTING DISORDER CAN PATIENTS GO INTO AS A RESULT OF MALIGNANT HYPERTHERMIA?
DISSEMINATED INTRAVASCULAR COAGULATION (DIC)
COMPLICATION THAT ARISES FROM MALIGNANT HYPERTHERMIA
WHAT IS CARDIAC ARREST, BRIAN DAMAGE, FAILURE OF BODY SYSTEMS AND DEATH?
WHERE SHOULD YOU REFER THE PATIENT AND THEIR FAMILY AFTER A MALIGNANT HYPERTHERMIA EVENT?
MHAUS/ MALIGNANT HYPERTHERMIA ASSOCIATION OF THE UNITED STATES
WHAT RESPIRATORY AND METABOLIC CHANGES HAPPEN IN MALIGNANT HYPERTHERMIA?
C. RESPIRATORY & METABOLIC ACIDOSIS