T Cell Biology
The two main co-receptors that interact with MHC on T cells
CD8 and CD4
CAR stands for
What is Chimeric Antigen Receptor?
The two mechanisms of T cell killing
What are perforin/granzyme and death receptor/ligand?
A CAR with CD3, CD28, and OX40 domains would be a ... generation CAR
What is third generation?
A type of CD4 T cell that adds to immunosuppression of cancer microenvironment
A possible mechanism for gene transfer in the production of CAR T cells
What is lentiviral transfer?
The possible effect of a mutation resulting in no functional CD28 on naive T cells
What is co-stimulation would be compromised, perhaps leading to impaired activation of T cells, although other co-stimulatory receptors also exist that could compensate to some degree (e.g. OX40)
A major challenge for using CAR T cells for the treatment of solid tumours
Immunosuppressive factors
Immunosuppressive cells
Trafficking to tumours
Inhibitory checkpoints