Mass Analyzers
Four parallel rods
What is a quadropole?
Soft, liquid, Taylor Cone
What is ESI?
One may argue this is the most common detector
What is an electron multiplier?
These large molecules do many things - provide structure, lower activation energies, among many other roles
What are proteins?
Used for solid or dried sample and charge is potentially transferred in the gas phase.
What is MALDI-MS? (Matrix Assisted Laser Desorption Ionization Mass Spec)
If you were an ion you may ask "Are we there yet?"
What is Time-of-flight?
Ions generated from this method are usually compared to the NIST database
What is EI? (Electron impact/electron bombardment)
What is a photomultiplier?
Sweet and best analyzed by negative mode
What are sugars?
This mass-spec technique first separates compounds based on their boiling point
What is GC-MS? (Gas-chromatography mass spec)
Ions flying around a small magnet, made by Thermo Fisher
What is an Orbitrap?
This hard-ionization source is hot, 6000 K hot!
This trademarked detector is also a mass analyzer
What is an Orbitrap?
MRLKEAG or CGACLIEGC for example
What are peptides?
Used for studying folded protein and protein complexes
What is NMS? (Native Mass Spectrometry)
Large magnet surrounding the ion
What is a cyclotron? (FT-ICR)
If you are a solid in trouble, you could ask your friend Neo
What is MALDI? (MATRIX assisted laser desorption ionization)
In a detector, these are made of Al2O3, BeO, GaP, or CsSb
What are dynodes?
These molecules can hold degrees from doubles
What are lipids?
Did I gain weight, or was that D2O?
What is HDX? (Hydrogen-deuterium exchange)
Paul might say "Help! I'm stuck!"
What is an ion trap?
Help! I'm a liquid under attack by Xenon!
What is FAB? (Fast Atom Bombardment)
A striking ion is converted to an electron which induces a positive current on this detector
What is a Faraday Cup?
This class of biomolecules comes from Greek for "change"
What are metabolites?
Using 3 quadrupoles, this targeted method only monitors a single precursor-product ion transition.
What is SRM? (Selected Reaction Monitoring)