Sarcoma
MPN
Not Medical
Neuro Onc
Photo Finish
100
GIST tumors most commonly have what 2 mutations
cKIT and PDGFRa
100
What 2 KIT inhibitors can be used for the treatment of systemic mastocytosis
Avapritinib and midostaurin
100
Beyoncé rose to fame in the late 1990s as the lead singer of what R&B girl-group?
Destiny's Child
100
For grade 1 CNS tumors that have a gross total resection, what is recommended next?
Observation
100
Erythromelalgia
200
Ewing's Sarcoma most commonly has what gene fusion
EWSR1-FLI1
200
The CSF3R mutation is found in 90% of what MPN
Chronic neutrophilic leukemia
200
What is the 2nd highest mountain on Earth?
K2
200
This virus can be associated with primary CNS lymphoma in immunocompromised patients
EBV
200
XR shows "sunburst pattern" - dx?
Osteosarcoma
300
Imatinib has an approval for what 2 types of sarcoma
Dermatofibrosarcoma protuberans and GIST
300
This pathway is spared by pacritinib, allowing for use in patient with thrombocytopenia
JAK 1
300
Which movie was incorrectly announced as the winner of Best Picture at the 2017 Academy Awards?
La La Land
300
MGMT methylation in GBM results in improved OS when treated with what medication?
Temozolomide (alkylating agent)
300
Top differential
GBM
400
This is the only FDA approved therapy for advanced epithelioid sarcoma
tazemetostat
400
Max dose of ruxolitinib for myelofibrosis pt with platelet count between 50K to 100K
5 mg BID
400
Which spice is derived from the Crocus flower
Saffron
400
Having this mutation gives glioma a more favorable prognosis
IDH1 mutation
400
XR shows "onion-skinning" - dx?
Ewing Sarcoma
500
Pexidartinib is used to treat tenosynovial giant cell tumors, what is the MOA?
CSF1R inhibitor
500
This FISH result is surrogate for FIP1L1PDGRFA as there is not a cytogenetic rearrangement detected
CHIC2
500
This new sport will be added to the 2024 summer Olympics
Breaking (break-dancing)
500
What dose of Methotrexate = "high-dose" systemically, and has the ability to penetrate the BBB
>/= 3.5 g/m2
500
What is this called and how many hours a day must it be worn for best results?
Optune or Tumor Treating Fields (TTF) - >18hr/day