Bioinformatics FUN FACTS
This was the college major of Steven Altschul, the lead author of BLAST.
This is the full word for the abbreviation eQTL.
What is expression quantitative trait loci?
Microbiome composition was found to be correlated with these characteristics of the host.
What are genetic variation and gene pathways.
New research in the past year showed: Phagocytosis of synaptic elements, essentially damaging the brain, will occur by a mammalian brain’s “cleaning system” if subject to this.
What is chronic, severe sleep deprivation?
A genomic variant that occurs in populations at frequencies > 1%.
What is a Polymorphism?
She is known as the founder of bioinformatics, developing ideas re “evolutionary trees” before systematics was proposed, creating the one letter amino acid code, creating the first similarity matrix (PAM), and in 1971 launched the first ever on-line database system (Protein Information Resource) that could be publicly accessed by telephone line.
Who is Margaret Dayhoff?
These are some limitations of some existing enhancer prediction software.
What are centers/boundaries of predictions not well defined, performed worse on cells/tissue types different from training data, and neglect variation between cell/tissue types.
This is the difference between alpha diversity and beta diversity.
What is alpha diversity measures diversity within samples, and beta diversity measures diversity between samples?
A year ago today it was reported that this part of the body in mice, and likely humans, plays an important role in the biogenesis of blood platelets.
What are your lungs? https://www.nature.com/articles/nature21706
This type of mutation increases the fitness of a cell, or otherwise aids its progression towards a neoplasm.
What is a driver mutation?
The first base undergraduate curricula for bioinformatics training in Canada was based on an undergraduate program developed here.
REPTILE predicts enhancers by integrating these things.
What are whole genome, base resolution cell/tissue specific cytosine DNA methylation data, and lower resolution histone modification data?
You have more microbial cells in your body than these types of cells.
What are ALL types of human cells in your body, collectively?!
As Simon Fraser University's first Chancellor, this Physicist recommended to the provincial government that SFU be located atop the summit of Burnaby Mountain.
Who is George Schrum?
These mutations have a neutral effect on cancer fitness, but may be associated with a clonal expansion.
What are passenger mutations?
This is the name of the longest continually running Bioinformatics Users Group in the world.
What is VanBUG?
These types of datasets were included in the compiled dataset in the paper “Evaluating the impact of single nucleotide variants on transcription factor binding.
What are WGS reads, TF ChIP-Seq reads?
This is the truth value of this statement: mammals do not show strong phylosymbiosis signals that decayed over evolutionary time.
What is false?
Stephen Hawking (may he rest in peace) performed research on this cosmic event.
What are black holes?
This type of genome modification involves regions of the genome being physically relocated, with no gain or loss of genomic material involved, potentially fusing genes or deregulating expression.
What are copy-neutral rearrangements?
David Lipman, the former director of NCBI, is now the Chief Science Officer of this company.
What is Impossible Foods?
In studying the impact of structural variation on human gene expression, whole genome sequencing provided these benefits.
What are greater sensitivity and accuracy?
The paper identifying protein structures using metagenomics data did not use eukaryotic sequences for this reason.
What is that eukaryotic microbiome genomes are too large and costly verses other microbiome genomes?
Frederick Sanger, namesake for Sanger Sequencing and the Sanger Institute, won the nobel prize for this.
What is his work on the structure of proteins, especially that of insulin?
This algorithm released by the Morin lab identifies discrete peaks of elevated mutation rate across Rainstorm plots from large datasets of cancer genomes.
What is the Doppler algorithm?