Somatic mutations and cancer
These types of tumours are cancerous and can invade local tissue and spread throughout the body.
What are malignant tumours?
This is the name given to a drug that, when bound to its target, elicits a response.
What is an agonist.
Immunogenomics primarily focuses on this aspect of the immune system.
What is the adaptive immune system?
Allogenic stem cell transfer involves giving cells to a patient that come from where?
What is a donor?
Neuronal communication is mediated by these.
What are spike trains?
Gain of function mutations primarily occur in these types of genes.
What are proto-oncogenes.
This type of drug needs to be metabolized into its active form.
What is a pro-drug.
These are the minimum and maximum HLA alleles an individual can have.
What are 3 and 6.
All methods of gene editing require the use of this cellular mechanism.
What is homologous repair.
Learning and memory are thought to be encoded by this mechanism.
What is long term potentiation (LTP)?
Sequencing data from these two types of tissue are required to identify somatic mutations.
What are normal and tumour tissue.
This word describes what a drug does to the body.
What is pharmacodynamics.
These cause the immune system to be suppressed unless specifically blocked.
What are checkpoint blockade molecules.
These two gene therapy modalities specifically affect the expression of a gene.
What are supplementation and elimination.
The delay in transition from embryoid body to neuroectoderm in humans allows for the creation of more of what kind of cell?
What are progenitor cells?
This type of drug can inhibit the growth of a tumour cell.
What is a cytostatic drug.
These four things define the process of pharmacokinetics.
What are adsorption, distribution, metabolism, excretion (ADME)
The most conserved positions in a 9-mer epitope that binds to an MHC are these.
What are 2 and 9.
Lentiviral gene therapy creates virus particles that are non replicative because of this method.
What is putting the viral proteins (gag/pol/env) on different plasmids.
This group of people are more susceptible of developing schitzophrenia.
What are monozygotic twins?
A stage 3 tumour has these characteristics.
What are moderate in size with lymph node involvement.
This beta adrenergic receptor is associated with smooth muscle but not cardiac muscle.
What is the Beta2 receptor
This is what T-cell receptors specifically recognise.
What is peptide in the context of MHC.
Chimeric antigen receptors combine these two things (plus costimulatory signals).
What is the antibody-like domain (B-cell) and intracellular (T-cell) domain.
This term refers to the fact that we don't know all genetic factors that account for the development of a disease.
What is missing heritability?