Insane in the Membrane
Whats My Membrane Problem?
Nucleous-schmucleous
Bad Nucleous
Get In/ Get out
100
These general class of molecules are responsible for increasing the rigidity of the plasma membrane
What is cholesterol
100
A cell found in the ER membrane is living longer than it should. A defect in this enzyme could explain why.
What is scrambalase (32)
100
During nuclear envelope disassembly, this compound remains attached to the inner membrane
What is Lamin B
100
You patient has muscle weakness/atrophy, hypotonia, dysphagia, and feeding difficulties. You notice a loss of motor neurons. A mutation in this protein could explain his symptoms
What is SMN (survival motor neurons) (78)
100
This molecule is responsible for recognizing signal-bound receptors and arranging clathrin
What is adaptin
200
The two leaflets of the plasma membrane are held together by these kinds of forces
What is van der Waals (21)
200
Hey doc! I have this boozehound patient with a massive spleen and his cholesterol is off the charts. He has yellowing of the sclera and portal hypertension. I also noticed his red blood cells are spur shaped. What disease do you think he has
What is Acanthocytosis
200
The perinuclear space is continuous with this structre
What is the ER lumen (53)
200
A gentleman walks into your gym, not wearing a shirt, and you notice his ripped abs. As you move closer, you notice his face is too fat for his body. He could possibly have a defect in which protien(s)
What is Lamin A/C (will also accept preLamin A)
200
Familial hypercholesterolemia is a defect in the LDL-r not clustering. The mutation class that this belongs to is
What is Class 4 mutation
300
Butter islands are rich in cholesterol and glycosphingolipits. Clustering of these compounds allows for for this function.
What is transport into endocytic vesicles
300
This receptor, found on intestinal epithelail cells, is responsible for responding to the cholera toxin
What is Gm1 Ganglioside
300
Nucleoporins make up the nuclear pore complex. Nucleoporins are made of this compound
300
You observe the cells of a child that looks like a 30 year old man. You find that he has altered Lamin A. Upon further examination you find what 3 strange things about his nucleous
What is Bleb formation, loss of peripheral heterochromatin, and NPC clustering
300
I fed my baby old Gerber apple sauce from the 1950s. I found a can of it in my grandmothers pantry. All of a sudden my baby cannot move. What is wrong with my baby
What is botulism:flaccid paralysis
400
This compound binds actin to glycophorin and sprectrin to band 3 in red blood cells
What is protein 4.1 (39)
400
A deficiency in this protein would would cause splenomegaly, jaundice, and gall stones. However, if I give him folate supplements he will most likely be ok.
What is spectrin
400
This area of the nucleoulous contains transcriptionally inactive DNA
What is the Fibrillar center
400
A mutation of Emerin or Lamin A/C will produce Emery-Dreifuss muscular dystrophy. Sudden failure of this organ is common in these patients
What is the heart
400
A patient presents with dilated central bronchi, hyper expansion, irreversible bronchial dilation and thickened bronchial walls. You patient has a of mucoid impaction and a 2 year infection. She/he will most likely die of respiratory failure. The disease is most likely this
What is CF:Bronchiectasis
500
L-selectins recognise addressins on what type of enothelial cells
What are lymphoid organs / lymphocytes (45)
500
A new ant-cancer therapy was developed to treat cancer patients. Upon examination treatment cells (TrC) were unable to recognize the the outer sugar coating of the the target cells (TaC) A defect in this could explain why
What is Glycocalyx
500
The nucleolus is responsible for producing all of our rRNA's except for this one. Which is made by RNA pol III elsewhere
What is 5S rRNA
500
Examination the cells of a patient with Emery-Dreifuss muscular dystrophy would show that nor epinephrine has been disrupted and also this
What is chromatin extruded from the cytoplasm
500
Proteins that are destined to go to the lysosomes are tagged with this (in the cis-Golgi)
What is mannose-6-phosphate
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